DNA Polymerase Conformational Dynamics and the Role of Fidelity-Conferring Residues: Insights from Computational Simulations

Herein we investigate the molecular bases of DNA polymerase I conformational dynamics that underlie the replication fidelity of the enzyme. Such fidelity is determined by conformational changes that promote the rejection of incorrect nucleotides before the chemical ligation step. We report a compreh...

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Detalles Bibliográficos
Autores principales: Meli, Massimiliano, Sustarsic, Marko, Craggs, Timothy D., Kapanidis, Achillefs N., Colombo, Giorgio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4882331/
https://www.ncbi.nlm.nih.gov/pubmed/27303671
http://dx.doi.org/10.3389/fmolb.2016.00020

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4882331/
https://www.ncbi.nlm.nih.gov/pubmed/27303671
http://dx.doi.org/10.3389/fmolb.2016.00020

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