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Aeromonas dhakensis, an Increasingly Recognized Human Pathogen
Aeromonas dhakensis was first isolated from children with diarrhea in Dhaka, Bangladesh and described in 2002. In the past decade, increasing evidence indicate this species is widely distributed in the environment and can cause a variety of infections both in human and animals, especially in coastal...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2016
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4882333/ https://www.ncbi.nlm.nih.gov/pubmed/27303382 http://dx.doi.org/10.3389/fmicb.2016.00793 |
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author | Chen, Po-Lin Lamy, Brigitte Ko, Wen-Chien |
author_facet | Chen, Po-Lin Lamy, Brigitte Ko, Wen-Chien |
author_sort | Chen, Po-Lin |
collection | PubMed |
description | Aeromonas dhakensis was first isolated from children with diarrhea in Dhaka, Bangladesh and described in 2002. In the past decade, increasing evidence indicate this species is widely distributed in the environment and can cause a variety of infections both in human and animals, especially in coastal areas. A. dhakensis is often misidentified as A. hydrophila, A. veronii, or A. caviae by commercial phenotypic tests in the clinical laboratory. Correct identification relies on molecular methods. Increasingly used matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) may be able to identify Aeromonas specie rapidly and accurately. A. dhakensis has shown its potent virulence in different animal models and clinical infections. Although several virulence factors had been reported, no single mechanism is conclusive. Characteristically A. dhakensis is the principal species causing soft tissue infection and bacteremia, especially among patients with liver cirrhosis or malignancy. Of note, A. dhakensis bacteremia is more lethal than bacteremia due to other Aeromonas species. The role of this species in gastroenteritis remains controversial. Third generation cephalosporins and carbapenems should be used cautiously in the treatment of severe A. dhakensis infection due to the presence of AmpC ββ-lactamase and metallo-β-lactamase genes, and optimal regimens may be cefepime or fluoroquinolones. Studies of bacterial virulence factors and associated host responses may provide the chance to understand the heterogeneous virulence between species. The hypothesis A. dhakensis with varied geographic prevalence and enhanced virulence that compared to other Aeromonas species warrants more investigations. |
format | Online Article Text |
id | pubmed-4882333 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-48823332016-06-14 Aeromonas dhakensis, an Increasingly Recognized Human Pathogen Chen, Po-Lin Lamy, Brigitte Ko, Wen-Chien Front Microbiol Microbiology Aeromonas dhakensis was first isolated from children with diarrhea in Dhaka, Bangladesh and described in 2002. In the past decade, increasing evidence indicate this species is widely distributed in the environment and can cause a variety of infections both in human and animals, especially in coastal areas. A. dhakensis is often misidentified as A. hydrophila, A. veronii, or A. caviae by commercial phenotypic tests in the clinical laboratory. Correct identification relies on molecular methods. Increasingly used matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) may be able to identify Aeromonas specie rapidly and accurately. A. dhakensis has shown its potent virulence in different animal models and clinical infections. Although several virulence factors had been reported, no single mechanism is conclusive. Characteristically A. dhakensis is the principal species causing soft tissue infection and bacteremia, especially among patients with liver cirrhosis or malignancy. Of note, A. dhakensis bacteremia is more lethal than bacteremia due to other Aeromonas species. The role of this species in gastroenteritis remains controversial. Third generation cephalosporins and carbapenems should be used cautiously in the treatment of severe A. dhakensis infection due to the presence of AmpC ββ-lactamase and metallo-β-lactamase genes, and optimal regimens may be cefepime or fluoroquinolones. Studies of bacterial virulence factors and associated host responses may provide the chance to understand the heterogeneous virulence between species. The hypothesis A. dhakensis with varied geographic prevalence and enhanced virulence that compared to other Aeromonas species warrants more investigations. Frontiers Media S.A. 2016-05-27 /pmc/articles/PMC4882333/ /pubmed/27303382 http://dx.doi.org/10.3389/fmicb.2016.00793 Text en Copyright © 2016 Chen, Lamy and Ko. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Microbiology Chen, Po-Lin Lamy, Brigitte Ko, Wen-Chien Aeromonas dhakensis, an Increasingly Recognized Human Pathogen |
title | Aeromonas dhakensis, an Increasingly Recognized Human Pathogen |
title_full | Aeromonas dhakensis, an Increasingly Recognized Human Pathogen |
title_fullStr | Aeromonas dhakensis, an Increasingly Recognized Human Pathogen |
title_full_unstemmed | Aeromonas dhakensis, an Increasingly Recognized Human Pathogen |
title_short | Aeromonas dhakensis, an Increasingly Recognized Human Pathogen |
title_sort | aeromonas dhakensis, an increasingly recognized human pathogen |
topic | Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4882333/ https://www.ncbi.nlm.nih.gov/pubmed/27303382 http://dx.doi.org/10.3389/fmicb.2016.00793 |
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