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Combinatorial development of antibacterial Zr-Cu-Al-Ag thin film metallic glasses
Metallic alloys are normally composed of multiple constituent elements in order to achieve integration of a plurality of properties required in technological applications. However, conventional alloy development paradigm, by sequential trial-and-error approach, requires completely unrelated strategi...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4882501/ https://www.ncbi.nlm.nih.gov/pubmed/27230692 http://dx.doi.org/10.1038/srep26950 |
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author | Liu, Yanhui Padmanabhan, Jagannath Cheung, Bettina Liu, Jingbei Chen, Zheng Scanley, B. Ellen Wesolowski, Donna Pressley, Mariyah Broadbridge, Christine C. Altman, Sidney Schwarz, Udo D. Kyriakides, Themis R. Schroers, Jan |
author_facet | Liu, Yanhui Padmanabhan, Jagannath Cheung, Bettina Liu, Jingbei Chen, Zheng Scanley, B. Ellen Wesolowski, Donna Pressley, Mariyah Broadbridge, Christine C. Altman, Sidney Schwarz, Udo D. Kyriakides, Themis R. Schroers, Jan |
author_sort | Liu, Yanhui |
collection | PubMed |
description | Metallic alloys are normally composed of multiple constituent elements in order to achieve integration of a plurality of properties required in technological applications. However, conventional alloy development paradigm, by sequential trial-and-error approach, requires completely unrelated strategies to optimize compositions out of a vast phase space, making alloy development time consuming and labor intensive. Here, we challenge the conventional paradigm by proposing a combinatorial strategy that enables parallel screening of a multitude of alloys. Utilizing a typical metallic glass forming alloy system Zr-Cu-Al-Ag as an example, we demonstrate how glass formation and antibacterial activity, two unrelated properties, can be simultaneously characterized and the optimal composition can be efficiently identified. We found that in the Zr-Cu-Al-Ag alloy system fully glassy phase can be obtained in a wide compositional range by co-sputtering, and antibacterial activity is strongly dependent on alloy compositions. Our results indicate that antibacterial activity is sensitive to Cu and Ag while essentially remains unchanged within a wide range of Zr and Al. The proposed strategy not only facilitates development of high-performing alloys, but also provides a tool to unveil the composition dependence of properties in a highly parallel fashion, which helps the development of new materials by design. |
format | Online Article Text |
id | pubmed-4882501 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-48825012016-06-08 Combinatorial development of antibacterial Zr-Cu-Al-Ag thin film metallic glasses Liu, Yanhui Padmanabhan, Jagannath Cheung, Bettina Liu, Jingbei Chen, Zheng Scanley, B. Ellen Wesolowski, Donna Pressley, Mariyah Broadbridge, Christine C. Altman, Sidney Schwarz, Udo D. Kyriakides, Themis R. Schroers, Jan Sci Rep Article Metallic alloys are normally composed of multiple constituent elements in order to achieve integration of a plurality of properties required in technological applications. However, conventional alloy development paradigm, by sequential trial-and-error approach, requires completely unrelated strategies to optimize compositions out of a vast phase space, making alloy development time consuming and labor intensive. Here, we challenge the conventional paradigm by proposing a combinatorial strategy that enables parallel screening of a multitude of alloys. Utilizing a typical metallic glass forming alloy system Zr-Cu-Al-Ag as an example, we demonstrate how glass formation and antibacterial activity, two unrelated properties, can be simultaneously characterized and the optimal composition can be efficiently identified. We found that in the Zr-Cu-Al-Ag alloy system fully glassy phase can be obtained in a wide compositional range by co-sputtering, and antibacterial activity is strongly dependent on alloy compositions. Our results indicate that antibacterial activity is sensitive to Cu and Ag while essentially remains unchanged within a wide range of Zr and Al. The proposed strategy not only facilitates development of high-performing alloys, but also provides a tool to unveil the composition dependence of properties in a highly parallel fashion, which helps the development of new materials by design. Nature Publishing Group 2016-05-27 /pmc/articles/PMC4882501/ /pubmed/27230692 http://dx.doi.org/10.1038/srep26950 Text en Copyright © 2016, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Liu, Yanhui Padmanabhan, Jagannath Cheung, Bettina Liu, Jingbei Chen, Zheng Scanley, B. Ellen Wesolowski, Donna Pressley, Mariyah Broadbridge, Christine C. Altman, Sidney Schwarz, Udo D. Kyriakides, Themis R. Schroers, Jan Combinatorial development of antibacterial Zr-Cu-Al-Ag thin film metallic glasses |
title | Combinatorial development of antibacterial Zr-Cu-Al-Ag thin film metallic glasses |
title_full | Combinatorial development of antibacterial Zr-Cu-Al-Ag thin film metallic glasses |
title_fullStr | Combinatorial development of antibacterial Zr-Cu-Al-Ag thin film metallic glasses |
title_full_unstemmed | Combinatorial development of antibacterial Zr-Cu-Al-Ag thin film metallic glasses |
title_short | Combinatorial development of antibacterial Zr-Cu-Al-Ag thin film metallic glasses |
title_sort | combinatorial development of antibacterial zr-cu-al-ag thin film metallic glasses |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4882501/ https://www.ncbi.nlm.nih.gov/pubmed/27230692 http://dx.doi.org/10.1038/srep26950 |
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