Mechanism of impaired microtubule-dependent peroxisome trafficking and oxidative stress in SPAST-mutated cells from patients with Hereditary Spastic Paraplegia

Hereditary spastic paraplegia (HSP) is an inherited neurological condition that leads to progressive spasticity and gait abnormalities. Adult-onset HSP is most commonly caused by mutations in SPAST, which encodes spastin a microtubule severing protein. In olfactory stem cell lines derived from patie...

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Detalles Bibliográficos
Autores principales: Wali, Gautam, Sutharsan, Ratneswary, Fan, Yongjun, Stewart, Romal, Tello Velasquez, Johana, Sue, Carolyn M, Crane, Denis I., Mackay-Sim, Alan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4882512/
https://www.ncbi.nlm.nih.gov/pubmed/27229699
http://dx.doi.org/10.1038/srep27004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4882512/
https://www.ncbi.nlm.nih.gov/pubmed/27229699
http://dx.doi.org/10.1038/srep27004

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