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Bioprospecting Sponge-Associated Microbes for Antimicrobial Compounds

Sponges are the most prolific marine organisms with respect to their arsenal of bioactive compounds including antimicrobials. However, the majority of these substances are probably not produced by the sponge itself, but rather by bacteria or fungi that are associated with their host. This review for...

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Autores principales: Indraningrat, Anak Agung Gede, Smidt, Hauke, Sipkema, Detmer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4882561/
https://www.ncbi.nlm.nih.gov/pubmed/27144573
http://dx.doi.org/10.3390/md14050087
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author Indraningrat, Anak Agung Gede
Smidt, Hauke
Sipkema, Detmer
author_facet Indraningrat, Anak Agung Gede
Smidt, Hauke
Sipkema, Detmer
author_sort Indraningrat, Anak Agung Gede
collection PubMed
description Sponges are the most prolific marine organisms with respect to their arsenal of bioactive compounds including antimicrobials. However, the majority of these substances are probably not produced by the sponge itself, but rather by bacteria or fungi that are associated with their host. This review for the first time provides a comprehensive overview of antimicrobial compounds that are known to be produced by sponge-associated microbes. We discuss the current state-of-the-art by grouping the bioactive compounds produced by sponge-associated microorganisms in four categories: antiviral, antibacterial, antifungal and antiprotozoal compounds. Based on in vitro activity tests, identified targets of potent antimicrobial substances derived from sponge-associated microbes include: human immunodeficiency virus 1 (HIV-1) (2-undecyl-4-quinolone, sorbicillactone A and chartarutine B); influenza A (H1N1) virus (truncateol M); nosocomial Gram positive bacteria (thiopeptide YM-266183, YM-266184, mayamycin and kocurin); Escherichia coli (sydonic acid), Chlamydia trachomatis (naphthacene glycoside SF2446A2); Plasmodium spp. (manzamine A and quinolone 1); Leishmania donovani (manzamine A and valinomycin); Trypanosoma brucei (valinomycin and staurosporine); Candida albicans and dermatophytic fungi (saadamycin, 5,7-dimethoxy-4-p-methoxylphenylcoumarin and YM-202204). Thirty-five bacterial and 12 fungal genera associated with sponges that produce antimicrobials were identified, with Streptomyces, Pseudovibrio, Bacillus, Aspergillus and Penicillium as the prominent producers of antimicrobial compounds. Furthemore culture-independent approaches to more comprehensively exploit the genetic richness of antimicrobial compound-producing pathways from sponge-associated bacteria are addressed.
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spelling pubmed-48825612016-05-27 Bioprospecting Sponge-Associated Microbes for Antimicrobial Compounds Indraningrat, Anak Agung Gede Smidt, Hauke Sipkema, Detmer Mar Drugs Review Sponges are the most prolific marine organisms with respect to their arsenal of bioactive compounds including antimicrobials. However, the majority of these substances are probably not produced by the sponge itself, but rather by bacteria or fungi that are associated with their host. This review for the first time provides a comprehensive overview of antimicrobial compounds that are known to be produced by sponge-associated microbes. We discuss the current state-of-the-art by grouping the bioactive compounds produced by sponge-associated microorganisms in four categories: antiviral, antibacterial, antifungal and antiprotozoal compounds. Based on in vitro activity tests, identified targets of potent antimicrobial substances derived from sponge-associated microbes include: human immunodeficiency virus 1 (HIV-1) (2-undecyl-4-quinolone, sorbicillactone A and chartarutine B); influenza A (H1N1) virus (truncateol M); nosocomial Gram positive bacteria (thiopeptide YM-266183, YM-266184, mayamycin and kocurin); Escherichia coli (sydonic acid), Chlamydia trachomatis (naphthacene glycoside SF2446A2); Plasmodium spp. (manzamine A and quinolone 1); Leishmania donovani (manzamine A and valinomycin); Trypanosoma brucei (valinomycin and staurosporine); Candida albicans and dermatophytic fungi (saadamycin, 5,7-dimethoxy-4-p-methoxylphenylcoumarin and YM-202204). Thirty-five bacterial and 12 fungal genera associated with sponges that produce antimicrobials were identified, with Streptomyces, Pseudovibrio, Bacillus, Aspergillus and Penicillium as the prominent producers of antimicrobial compounds. Furthemore culture-independent approaches to more comprehensively exploit the genetic richness of antimicrobial compound-producing pathways from sponge-associated bacteria are addressed. MDPI 2016-05-02 /pmc/articles/PMC4882561/ /pubmed/27144573 http://dx.doi.org/10.3390/md14050087 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Indraningrat, Anak Agung Gede
Smidt, Hauke
Sipkema, Detmer
Bioprospecting Sponge-Associated Microbes for Antimicrobial Compounds
title Bioprospecting Sponge-Associated Microbes for Antimicrobial Compounds
title_full Bioprospecting Sponge-Associated Microbes for Antimicrobial Compounds
title_fullStr Bioprospecting Sponge-Associated Microbes for Antimicrobial Compounds
title_full_unstemmed Bioprospecting Sponge-Associated Microbes for Antimicrobial Compounds
title_short Bioprospecting Sponge-Associated Microbes for Antimicrobial Compounds
title_sort bioprospecting sponge-associated microbes for antimicrobial compounds
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4882561/
https://www.ncbi.nlm.nih.gov/pubmed/27144573
http://dx.doi.org/10.3390/md14050087
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