Restrictive influence of SAMHD1 on Hepatitis B Virus life cycle

Deoxynucleotide triphosphates (dNTPs) are essential for efficient hepatitis B virus (HBV) replication. Here, we investigated the influence of the restriction factor SAMHD1, a dNTP hydrolase (dNTPase) and RNase, on HBV replication. We demonstrated that silencing of SAMHD1 in hepatic cells increased H...

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Detalles Bibliográficos
Autores principales: Sommer, Andreas F. R., Rivière, Lise, Qu, Bingqian, Schott, Kerstin, Riess, Maximilian, Ni, Yi, Shepard, Caitlin, Schnellbächer, Esther, Finkernagel, Malin, Himmelsbach, Kiyoshi, Welzel, Karin, Kettern, Nadja, Donnerhak, Christian, Münk, Carsten, Flory, Egbert, Liese, Juliane, Kim, Baek, Urban, Stephan, König, Renate
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4882586/
https://www.ncbi.nlm.nih.gov/pubmed/27229711
http://dx.doi.org/10.1038/srep26616

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