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The Possible Role of Flavonoids in the Prevention of Diabetic Complications

Type 2 diabetes mellitus is a disease that affects many metabolic pathways. It is associated with insulin resistance, impaired insulin signaling, β-cell dysfunction, abnormal glucose levels, altered lipid metabolism, sub-clinical inflammation and increased oxidative stress. These and other unknown m...

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Autores principales: Testa, Roberto, Bonfigli, Anna Rita, Genovese, Stefano, De Nigris, Valeria, Ceriello, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4882722/
https://www.ncbi.nlm.nih.gov/pubmed/27213445
http://dx.doi.org/10.3390/nu8050310
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author Testa, Roberto
Bonfigli, Anna Rita
Genovese, Stefano
De Nigris, Valeria
Ceriello, Antonio
author_facet Testa, Roberto
Bonfigli, Anna Rita
Genovese, Stefano
De Nigris, Valeria
Ceriello, Antonio
author_sort Testa, Roberto
collection PubMed
description Type 2 diabetes mellitus is a disease that affects many metabolic pathways. It is associated with insulin resistance, impaired insulin signaling, β-cell dysfunction, abnormal glucose levels, altered lipid metabolism, sub-clinical inflammation and increased oxidative stress. These and other unknown mechanisms lead to micro- and macro-complications, such as neuropathy, retinopathy, nephropathy and cardiovascular disease. Based on several in vitro animal models and some human studies, flavonoids appear to play a role in many of the metabolic processes involved in type 2 diabetes mellitus. In this review, we seek to highlight the most recent papers focusing on the relationship between flavonoids and main diabetic complications.
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spelling pubmed-48827222016-05-27 The Possible Role of Flavonoids in the Prevention of Diabetic Complications Testa, Roberto Bonfigli, Anna Rita Genovese, Stefano De Nigris, Valeria Ceriello, Antonio Nutrients Review Type 2 diabetes mellitus is a disease that affects many metabolic pathways. It is associated with insulin resistance, impaired insulin signaling, β-cell dysfunction, abnormal glucose levels, altered lipid metabolism, sub-clinical inflammation and increased oxidative stress. These and other unknown mechanisms lead to micro- and macro-complications, such as neuropathy, retinopathy, nephropathy and cardiovascular disease. Based on several in vitro animal models and some human studies, flavonoids appear to play a role in many of the metabolic processes involved in type 2 diabetes mellitus. In this review, we seek to highlight the most recent papers focusing on the relationship between flavonoids and main diabetic complications. MDPI 2016-05-20 /pmc/articles/PMC4882722/ /pubmed/27213445 http://dx.doi.org/10.3390/nu8050310 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Testa, Roberto
Bonfigli, Anna Rita
Genovese, Stefano
De Nigris, Valeria
Ceriello, Antonio
The Possible Role of Flavonoids in the Prevention of Diabetic Complications
title The Possible Role of Flavonoids in the Prevention of Diabetic Complications
title_full The Possible Role of Flavonoids in the Prevention of Diabetic Complications
title_fullStr The Possible Role of Flavonoids in the Prevention of Diabetic Complications
title_full_unstemmed The Possible Role of Flavonoids in the Prevention of Diabetic Complications
title_short The Possible Role of Flavonoids in the Prevention of Diabetic Complications
title_sort possible role of flavonoids in the prevention of diabetic complications
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4882722/
https://www.ncbi.nlm.nih.gov/pubmed/27213445
http://dx.doi.org/10.3390/nu8050310
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