Detection of Active Mammalian GH31 α-Glucosidases in Health and Disease Using In-Class, Broad-Spectrum Activity-Based Probes

[Image: see text] The development of small molecule activity-based probes (ABPs) is an evolving and powerful area of chemistry. There is a major need for synthetically accessible and specific ABPs to advance our understanding of enzymes in health and disease. α-Glucosidases are involved in diverse p...

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Detalles Bibliográficos
Autores principales: Jiang, Jianbing, Kuo, Chi-Lin, Wu, Liang, Franke, Christian, Kallemeijn, Wouter W., Florea, Bogdan I., van Meel, Eline, van der Marel, Gijsbert A., Codée, Jeroen D. C., Boot, Rolf G., Davies, Gideon J., Overkleeft, Herman S., Aerts, Johannes M. F. G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2016
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4882745/
https://www.ncbi.nlm.nih.gov/pubmed/27280170
http://dx.doi.org/10.1021/acscentsci.6b00057

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