Protective effect of sildenafil on the genotoxicity and cytotoxicity in apolipoprotein E-deficient mice bone marrow cells

BACKGROUND: The pharmacological inhibitor of phosphodiesterase 5 (PDE5), sildenafil, is a promising candidate for antioxidant therapy that can result in cardiovascular protection. In addition to its known effects on the cardiovascular system, hypercholesterolemia leads to increased oxidative stress...

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Detalles Bibliográficos
Autores principales: Bernardes, Franciane P., Batista, Alan T., Porto, Marcella L., Vasquez, Elisardo C., Campagnaro, Bianca P., Meyrelles, Silvana S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4882816/
https://www.ncbi.nlm.nih.gov/pubmed/27229150
http://dx.doi.org/10.1186/s12944-016-0268-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4882816/
https://www.ncbi.nlm.nih.gov/pubmed/27229150
http://dx.doi.org/10.1186/s12944-016-0268-6

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