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Protective effect of sildenafil on the genotoxicity and cytotoxicity in apolipoprotein E-deficient mice bone marrow cells
BACKGROUND: The pharmacological inhibitor of phosphodiesterase 5 (PDE5), sildenafil, is a promising candidate for antioxidant therapy that can result in cardiovascular protection. In addition to its known effects on the cardiovascular system, hypercholesterolemia leads to increased oxidative stress...
Autores principales: | Bernardes, Franciane P., Batista, Alan T., Porto, Marcella L., Vasquez, Elisardo C., Campagnaro, Bianca P., Meyrelles, Silvana S. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4882816/ https://www.ncbi.nlm.nih.gov/pubmed/27229150 http://dx.doi.org/10.1186/s12944-016-0268-6 |
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