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Research protocol for an epidemiological study on estimating disease burden of pediatric HIV in Belgaum district, India

BACKGROUND: Pediatric HIV is poised to become a major public health problem in India with the rising trend of HIV infection in pregnant women (Department of AIDS Control, Ministry of Health and Family Welfare, http://www.naco.gov.in). There is lack of information on the epidemiology of pediatric HIV...

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Autores principales: Sinha, Anju, Nath, Anita, Sethumadhavan, Rajeev, Isac, Shajy, Washington, Reynold
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4882840/
https://www.ncbi.nlm.nih.gov/pubmed/27228989
http://dx.doi.org/10.1186/s12889-016-3132-8
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author Sinha, Anju
Nath, Anita
Sethumadhavan, Rajeev
Isac, Shajy
Washington, Reynold
author_facet Sinha, Anju
Nath, Anita
Sethumadhavan, Rajeev
Isac, Shajy
Washington, Reynold
author_sort Sinha, Anju
collection PubMed
description BACKGROUND: Pediatric HIV is poised to become a major public health problem in India with the rising trend of HIV infection in pregnant women (Department of AIDS Control, Ministry of Health and Family Welfare, http://www.naco.gov.in). There is lack of information on the epidemiology of pediatric HIV infection in India. Existing surveillance systems tend to underestimate the Pediatric burden. The overall aim of the present study is to estimate the disease burden of pediatric HIV among children in Belgaum district in the state of Karnataka in Southern India. An innovative multipronged epidemiological approach to comb the district is proposed. METHODS: The primary objectives of the study would be attained under three strategies. A prospective cohort design for objective (i) to determine the incidence rate of HIV by early case detection in infants and toddlers (0–18 months) born to HIV infected pregnant women; and cross sectional design for objectives (ii) to determine the prevalence of HIV infection in children (0–14 years) of HIV infected parents and (iii) to determine the prevalence of HIV in sick children (0–14 years) presenting with suspected signs and symptoms using age specific criteria for screening. Burden of pediatric HIV will be calculated as a product of cases detected in each strategy multiplied by a net inflation factor for each strategy. Study participants (i) (ii) (iii): HIV infected pregnant women and their live born children (ii) Any HIV-infected man/woman, of age 18–49 years, having a biological child of age 0–14 years (iii) Sick children of age 0–14 years presenting with suspected signs and symptoms and satisfying age-specific criteria for screening. Setting and conduct: Belgaum district which is a Category ‘A’ district (with more than 1 % antenatal prevalence in the district over the last 3 years before the study). Age-appropriate testing is used to detect HIV infection. DISCUSSION: There is a need to strengthen existing pediatric HIV estimation methods in India and other developing countries. We hope that the novel methodology emanating from this study would be applicable for estimating the burden of HIV in other settings and it would be adaptable for estimating the burden of other infectious/chronic diseases. Findings from this study will give future direction to the national program for prevention and control of HIV in India and other developing countries. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12889-016-3132-8) contains supplementary material, which is available to authorized users.
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spelling pubmed-48828402016-05-28 Research protocol for an epidemiological study on estimating disease burden of pediatric HIV in Belgaum district, India Sinha, Anju Nath, Anita Sethumadhavan, Rajeev Isac, Shajy Washington, Reynold BMC Public Health Study Protocol BACKGROUND: Pediatric HIV is poised to become a major public health problem in India with the rising trend of HIV infection in pregnant women (Department of AIDS Control, Ministry of Health and Family Welfare, http://www.naco.gov.in). There is lack of information on the epidemiology of pediatric HIV infection in India. Existing surveillance systems tend to underestimate the Pediatric burden. The overall aim of the present study is to estimate the disease burden of pediatric HIV among children in Belgaum district in the state of Karnataka in Southern India. An innovative multipronged epidemiological approach to comb the district is proposed. METHODS: The primary objectives of the study would be attained under three strategies. A prospective cohort design for objective (i) to determine the incidence rate of HIV by early case detection in infants and toddlers (0–18 months) born to HIV infected pregnant women; and cross sectional design for objectives (ii) to determine the prevalence of HIV infection in children (0–14 years) of HIV infected parents and (iii) to determine the prevalence of HIV in sick children (0–14 years) presenting with suspected signs and symptoms using age specific criteria for screening. Burden of pediatric HIV will be calculated as a product of cases detected in each strategy multiplied by a net inflation factor for each strategy. Study participants (i) (ii) (iii): HIV infected pregnant women and their live born children (ii) Any HIV-infected man/woman, of age 18–49 years, having a biological child of age 0–14 years (iii) Sick children of age 0–14 years presenting with suspected signs and symptoms and satisfying age-specific criteria for screening. Setting and conduct: Belgaum district which is a Category ‘A’ district (with more than 1 % antenatal prevalence in the district over the last 3 years before the study). Age-appropriate testing is used to detect HIV infection. DISCUSSION: There is a need to strengthen existing pediatric HIV estimation methods in India and other developing countries. We hope that the novel methodology emanating from this study would be applicable for estimating the burden of HIV in other settings and it would be adaptable for estimating the burden of other infectious/chronic diseases. Findings from this study will give future direction to the national program for prevention and control of HIV in India and other developing countries. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12889-016-3132-8) contains supplementary material, which is available to authorized users. BioMed Central 2016-05-26 /pmc/articles/PMC4882840/ /pubmed/27228989 http://dx.doi.org/10.1186/s12889-016-3132-8 Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Study Protocol
Sinha, Anju
Nath, Anita
Sethumadhavan, Rajeev
Isac, Shajy
Washington, Reynold
Research protocol for an epidemiological study on estimating disease burden of pediatric HIV in Belgaum district, India
title Research protocol for an epidemiological study on estimating disease burden of pediatric HIV in Belgaum district, India
title_full Research protocol for an epidemiological study on estimating disease burden of pediatric HIV in Belgaum district, India
title_fullStr Research protocol for an epidemiological study on estimating disease burden of pediatric HIV in Belgaum district, India
title_full_unstemmed Research protocol for an epidemiological study on estimating disease burden of pediatric HIV in Belgaum district, India
title_short Research protocol for an epidemiological study on estimating disease burden of pediatric HIV in Belgaum district, India
title_sort research protocol for an epidemiological study on estimating disease burden of pediatric hiv in belgaum district, india
topic Study Protocol
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4882840/
https://www.ncbi.nlm.nih.gov/pubmed/27228989
http://dx.doi.org/10.1186/s12889-016-3132-8
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