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Disrupted rich club network in behavioral variant frontotemporal dementia and early‐onset Alzheimer's disease

In network analysis, the so‐called “rich club” describes the core areas of the brain that are more densely interconnected among themselves than expected by chance, and has been identified as a fundamental aspect of the human brain connectome. This is the first in‐depth diffusion imaging study to inv...

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Autores principales: Daianu, Madelaine, Mezher, Adam, Mendez, Mario F., Jahanshad, Neda, Jimenez, Elvira E., Thompson, Paul M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4883024/
https://www.ncbi.nlm.nih.gov/pubmed/26678225
http://dx.doi.org/10.1002/hbm.23069
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author Daianu, Madelaine
Mezher, Adam
Mendez, Mario F.
Jahanshad, Neda
Jimenez, Elvira E.
Thompson, Paul M.
author_facet Daianu, Madelaine
Mezher, Adam
Mendez, Mario F.
Jahanshad, Neda
Jimenez, Elvira E.
Thompson, Paul M.
author_sort Daianu, Madelaine
collection PubMed
description In network analysis, the so‐called “rich club” describes the core areas of the brain that are more densely interconnected among themselves than expected by chance, and has been identified as a fundamental aspect of the human brain connectome. This is the first in‐depth diffusion imaging study to investigate the rich club along with other organizational changes in the brain's anatomical network in behavioral frontotemporal dementia (bvFTD), and a matched cohort with early‐onset Alzheimer's disease (EOAD). Our study sheds light on how bvFTD and EOAD affect connectivity of white matter fiber pathways in the brain, revealing differences and commonalities in the connectome among the dementias. To analyze the breakdown in connectivity, we studied three groups: 20 bvFTD, 23 EOAD, and 37 healthy elderly controls. All participants were scanned with diffusion‐weighted magnetic resonance imaging (MRI), and based on whole‐brain probabilistic tractography and cortical parcellations, we analyzed the rich club of the brain's connectivity network. This revealed distinct patterns of disruption in both forms of dementia. In the connectome, we detected less disruption overall in EOAD than in bvFTD [false discovery rate (FDR) critical P (perm) = 5.7 × 10(−3), 10,000 permutations], with more involvement of richly interconnected areas of the brain (chi‐squared P = 1.4 × 10(−4))—predominantly posterior cognitive alterations. In bvFTD, we found a greater spread of disruption including the rich club (FDR critical P (perm) = 6 × 10(−4)), but especially more peripheral alterations (chi‐squared P = 6.5 × 10(−3)), particularly in medial frontal areas of the brain, in line with the known behavioral socioemotional deficits seen in these patients. Hum Brain Mapp 37:868–883, 2016. © 2015 The Authors. Human Brain Mapping Published by Wiley Periodicals, Inc.
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spelling pubmed-48830242017-03-01 Disrupted rich club network in behavioral variant frontotemporal dementia and early‐onset Alzheimer's disease Daianu, Madelaine Mezher, Adam Mendez, Mario F. Jahanshad, Neda Jimenez, Elvira E. Thompson, Paul M. Hum Brain Mapp Research Articles In network analysis, the so‐called “rich club” describes the core areas of the brain that are more densely interconnected among themselves than expected by chance, and has been identified as a fundamental aspect of the human brain connectome. This is the first in‐depth diffusion imaging study to investigate the rich club along with other organizational changes in the brain's anatomical network in behavioral frontotemporal dementia (bvFTD), and a matched cohort with early‐onset Alzheimer's disease (EOAD). Our study sheds light on how bvFTD and EOAD affect connectivity of white matter fiber pathways in the brain, revealing differences and commonalities in the connectome among the dementias. To analyze the breakdown in connectivity, we studied three groups: 20 bvFTD, 23 EOAD, and 37 healthy elderly controls. All participants were scanned with diffusion‐weighted magnetic resonance imaging (MRI), and based on whole‐brain probabilistic tractography and cortical parcellations, we analyzed the rich club of the brain's connectivity network. This revealed distinct patterns of disruption in both forms of dementia. In the connectome, we detected less disruption overall in EOAD than in bvFTD [false discovery rate (FDR) critical P (perm) = 5.7 × 10(−3), 10,000 permutations], with more involvement of richly interconnected areas of the brain (chi‐squared P = 1.4 × 10(−4))—predominantly posterior cognitive alterations. In bvFTD, we found a greater spread of disruption including the rich club (FDR critical P (perm) = 6 × 10(−4)), but especially more peripheral alterations (chi‐squared P = 6.5 × 10(−3)), particularly in medial frontal areas of the brain, in line with the known behavioral socioemotional deficits seen in these patients. Hum Brain Mapp 37:868–883, 2016. © 2015 The Authors. Human Brain Mapping Published by Wiley Periodicals, Inc. John Wiley and Sons Inc. 2015-12-17 /pmc/articles/PMC4883024/ /pubmed/26678225 http://dx.doi.org/10.1002/hbm.23069 Text en © 2015 The Authors. Human Brain Mapping Published by Wiley Periodicals, Inc. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Articles
Daianu, Madelaine
Mezher, Adam
Mendez, Mario F.
Jahanshad, Neda
Jimenez, Elvira E.
Thompson, Paul M.
Disrupted rich club network in behavioral variant frontotemporal dementia and early‐onset Alzheimer's disease
title Disrupted rich club network in behavioral variant frontotemporal dementia and early‐onset Alzheimer's disease
title_full Disrupted rich club network in behavioral variant frontotemporal dementia and early‐onset Alzheimer's disease
title_fullStr Disrupted rich club network in behavioral variant frontotemporal dementia and early‐onset Alzheimer's disease
title_full_unstemmed Disrupted rich club network in behavioral variant frontotemporal dementia and early‐onset Alzheimer's disease
title_short Disrupted rich club network in behavioral variant frontotemporal dementia and early‐onset Alzheimer's disease
title_sort disrupted rich club network in behavioral variant frontotemporal dementia and early‐onset alzheimer's disease
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4883024/
https://www.ncbi.nlm.nih.gov/pubmed/26678225
http://dx.doi.org/10.1002/hbm.23069
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