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Topoisomerase 1 Regulates Gene Expression in Neurons through Cleavage Complex-Dependent and -Independent Mechanisms

Topoisomerase 1 (TOP1) inhibitors, including camptothecin and topotecan, covalently trap TOP1 on DNA, creating cleavage complexes (cc’s) that must be resolved before gene transcription and DNA replication can proceed. We previously found that topotecan reduces the expression of long (>100 kb) gen...

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Detalles Bibliográficos
Autores principales:	Mabb, Angela M., Simon, Jeremy M., King, Ian F., Lee, Hyeong-Min, An, Lin-Kun, Philpot, Benjamin D., Zylka, Mark J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4883752/ https://www.ncbi.nlm.nih.gov/pubmed/27231886 http://dx.doi.org/10.1371/journal.pone.0156439

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