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Angelman Syndrome Protein Ube3a Regulates Synaptic Growth and Endocytosis by Inhibiting BMP Signaling in Drosophila
Altered expression of the E3 ubiquitin ligase UBE3A, which is involved in protein degradation through the proteasome-mediated pathway, is associated with neurodevelopmental and behavioral defects observed in Angelman syndrome (AS) and autism. However, little is known about the neuronal function of U...
Autores principales: | Li, Wenhua, Yao, Aiyu, Zhi, Hui, Kaur, Kuldeep, Zhu, Yong-chuan, Jia, Mingyue, Zhao, Hui, Wang, Qifu, Jin, Shan, Zhao, Guoli, Xiong, Zhi-Qi, Zhang, Yong Q. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4883773/ https://www.ncbi.nlm.nih.gov/pubmed/27232889 http://dx.doi.org/10.1371/journal.pgen.1006062 |
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