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A Tubular Biomaterial Construct Exhibiting a Negative Poisson’s Ratio

Developing functional small-diameter vascular grafts is an important objective in tissue engineering research. In this study, we address the problem of compliance mismatch by designing and developing a 3D tubular construct that has a negative Poisson’s ratio ν(xy) (NPR). NPR constructs have the uniq...

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Autores principales: Lee, Jin Woo, Soman, Pranav, Park, Jeong Hun, Chen, Shaochen, Cho, Dong-Woo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4883790/
https://www.ncbi.nlm.nih.gov/pubmed/27232181
http://dx.doi.org/10.1371/journal.pone.0155681
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author Lee, Jin Woo
Soman, Pranav
Park, Jeong Hun
Chen, Shaochen
Cho, Dong-Woo
author_facet Lee, Jin Woo
Soman, Pranav
Park, Jeong Hun
Chen, Shaochen
Cho, Dong-Woo
author_sort Lee, Jin Woo
collection PubMed
description Developing functional small-diameter vascular grafts is an important objective in tissue engineering research. In this study, we address the problem of compliance mismatch by designing and developing a 3D tubular construct that has a negative Poisson’s ratio ν(xy) (NPR). NPR constructs have the unique ability to expand transversely when pulled axially, thereby resulting in a highly-compliant tubular construct. In this work, we used projection stereolithography to 3D-print a planar NPR sheet composed of photosensitive poly(ethylene) glycol diacrylate biomaterial. We used a step-lithography exposure and a stitch process to scale up the projection printing process, and used the cut-missing rib unit design to develop a centimeter-scale NPR sheet, which was rolled up to form a tubular construct. The constructs had Poisson’s ratios of -0.6 ≤ ν(xy) ≤ -0.1. The NPR construct also supports higher cellular adhesion than does the construct that has positive ν(xy). Our NPR design offers a significant advance in the development of highly-compliant vascular grafts.
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spelling pubmed-48837902016-06-10 A Tubular Biomaterial Construct Exhibiting a Negative Poisson’s Ratio Lee, Jin Woo Soman, Pranav Park, Jeong Hun Chen, Shaochen Cho, Dong-Woo PLoS One Research Article Developing functional small-diameter vascular grafts is an important objective in tissue engineering research. In this study, we address the problem of compliance mismatch by designing and developing a 3D tubular construct that has a negative Poisson’s ratio ν(xy) (NPR). NPR constructs have the unique ability to expand transversely when pulled axially, thereby resulting in a highly-compliant tubular construct. In this work, we used projection stereolithography to 3D-print a planar NPR sheet composed of photosensitive poly(ethylene) glycol diacrylate biomaterial. We used a step-lithography exposure and a stitch process to scale up the projection printing process, and used the cut-missing rib unit design to develop a centimeter-scale NPR sheet, which was rolled up to form a tubular construct. The constructs had Poisson’s ratios of -0.6 ≤ ν(xy) ≤ -0.1. The NPR construct also supports higher cellular adhesion than does the construct that has positive ν(xy). Our NPR design offers a significant advance in the development of highly-compliant vascular grafts. Public Library of Science 2016-05-27 /pmc/articles/PMC4883790/ /pubmed/27232181 http://dx.doi.org/10.1371/journal.pone.0155681 Text en © 2016 Lee et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Lee, Jin Woo
Soman, Pranav
Park, Jeong Hun
Chen, Shaochen
Cho, Dong-Woo
A Tubular Biomaterial Construct Exhibiting a Negative Poisson’s Ratio
title A Tubular Biomaterial Construct Exhibiting a Negative Poisson’s Ratio
title_full A Tubular Biomaterial Construct Exhibiting a Negative Poisson’s Ratio
title_fullStr A Tubular Biomaterial Construct Exhibiting a Negative Poisson’s Ratio
title_full_unstemmed A Tubular Biomaterial Construct Exhibiting a Negative Poisson’s Ratio
title_short A Tubular Biomaterial Construct Exhibiting a Negative Poisson’s Ratio
title_sort tubular biomaterial construct exhibiting a negative poisson’s ratio
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4883790/
https://www.ncbi.nlm.nih.gov/pubmed/27232181
http://dx.doi.org/10.1371/journal.pone.0155681
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