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A Tubular Biomaterial Construct Exhibiting a Negative Poisson’s Ratio
Developing functional small-diameter vascular grafts is an important objective in tissue engineering research. In this study, we address the problem of compliance mismatch by designing and developing a 3D tubular construct that has a negative Poisson’s ratio ν(xy) (NPR). NPR constructs have the uniq...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4883790/ https://www.ncbi.nlm.nih.gov/pubmed/27232181 http://dx.doi.org/10.1371/journal.pone.0155681 |
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author | Lee, Jin Woo Soman, Pranav Park, Jeong Hun Chen, Shaochen Cho, Dong-Woo |
author_facet | Lee, Jin Woo Soman, Pranav Park, Jeong Hun Chen, Shaochen Cho, Dong-Woo |
author_sort | Lee, Jin Woo |
collection | PubMed |
description | Developing functional small-diameter vascular grafts is an important objective in tissue engineering research. In this study, we address the problem of compliance mismatch by designing and developing a 3D tubular construct that has a negative Poisson’s ratio ν(xy) (NPR). NPR constructs have the unique ability to expand transversely when pulled axially, thereby resulting in a highly-compliant tubular construct. In this work, we used projection stereolithography to 3D-print a planar NPR sheet composed of photosensitive poly(ethylene) glycol diacrylate biomaterial. We used a step-lithography exposure and a stitch process to scale up the projection printing process, and used the cut-missing rib unit design to develop a centimeter-scale NPR sheet, which was rolled up to form a tubular construct. The constructs had Poisson’s ratios of -0.6 ≤ ν(xy) ≤ -0.1. The NPR construct also supports higher cellular adhesion than does the construct that has positive ν(xy). Our NPR design offers a significant advance in the development of highly-compliant vascular grafts. |
format | Online Article Text |
id | pubmed-4883790 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-48837902016-06-10 A Tubular Biomaterial Construct Exhibiting a Negative Poisson’s Ratio Lee, Jin Woo Soman, Pranav Park, Jeong Hun Chen, Shaochen Cho, Dong-Woo PLoS One Research Article Developing functional small-diameter vascular grafts is an important objective in tissue engineering research. In this study, we address the problem of compliance mismatch by designing and developing a 3D tubular construct that has a negative Poisson’s ratio ν(xy) (NPR). NPR constructs have the unique ability to expand transversely when pulled axially, thereby resulting in a highly-compliant tubular construct. In this work, we used projection stereolithography to 3D-print a planar NPR sheet composed of photosensitive poly(ethylene) glycol diacrylate biomaterial. We used a step-lithography exposure and a stitch process to scale up the projection printing process, and used the cut-missing rib unit design to develop a centimeter-scale NPR sheet, which was rolled up to form a tubular construct. The constructs had Poisson’s ratios of -0.6 ≤ ν(xy) ≤ -0.1. The NPR construct also supports higher cellular adhesion than does the construct that has positive ν(xy). Our NPR design offers a significant advance in the development of highly-compliant vascular grafts. Public Library of Science 2016-05-27 /pmc/articles/PMC4883790/ /pubmed/27232181 http://dx.doi.org/10.1371/journal.pone.0155681 Text en © 2016 Lee et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Lee, Jin Woo Soman, Pranav Park, Jeong Hun Chen, Shaochen Cho, Dong-Woo A Tubular Biomaterial Construct Exhibiting a Negative Poisson’s Ratio |
title | A Tubular Biomaterial Construct Exhibiting a Negative Poisson’s Ratio |
title_full | A Tubular Biomaterial Construct Exhibiting a Negative Poisson’s Ratio |
title_fullStr | A Tubular Biomaterial Construct Exhibiting a Negative Poisson’s Ratio |
title_full_unstemmed | A Tubular Biomaterial Construct Exhibiting a Negative Poisson’s Ratio |
title_short | A Tubular Biomaterial Construct Exhibiting a Negative Poisson’s Ratio |
title_sort | tubular biomaterial construct exhibiting a negative poisson’s ratio |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4883790/ https://www.ncbi.nlm.nih.gov/pubmed/27232181 http://dx.doi.org/10.1371/journal.pone.0155681 |
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