The Seckel syndrome and centrosomal protein Ninein localizes asymmetrically to stem cell centrosomes but is not required for normal development, behavior, or DNA damage response in Drosophila

Ninein (Nin) is a centrosomal protein whose gene is mutated in Seckel syndrome (SCKL, MIM 210600), an inherited recessive disease that results in primordial dwarfism, cognitive deficiencies, and increased sensitivity to genotoxic stress. Nin regulates neural stem cell self-renewal, interkinetic nucl...

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Detalles Bibliográficos
Autores principales: Zheng, Yiming, Mennella, Vito, Marks, Steven, Wildonger, Jill, Elnagdi, Esraa, Agard, David, Megraw, Timothy L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2016
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4884065/
https://www.ncbi.nlm.nih.gov/pubmed/27053665
http://dx.doi.org/10.1091/mbc.E15-09-0655

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