Chronic interleukin-1 drives haematopoietic stem cells towards precocious myeloid differentiation at the expense of self-renewal

Haematopoietic stem cells (HSC) maintain lifelong blood production and increase blood cell numbers in response to chronic and acute injury. However, the mechanism(s) by which inflammatory insults are communicated to HSCs and their consequences for HSC activity remain largely unknown. Here, we demons...

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Detalles Bibliográficos
Autores principales: Pietras, Eric M., Mirantes-Barbeito, Cristina, Fong, Sarah, Loeffler, Dirk, Kovtonyuk, Larisa V., Zhang, SiYi, Lakshminarasimhan, Ranjani, Chin, Chih Peng, Techner, José-Marc, Will, Britta, Nerlov, Claus, Steidl, Ulrich, Manz, Markus G., Schroeder, Timm, Passegué, Emmanuelle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4884136/
https://www.ncbi.nlm.nih.gov/pubmed/27111842
http://dx.doi.org/10.1038/ncb3346

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