Role of Cardiac Myocytes Heart Fatty Acid Binding Protein Depletion (H-FABP) in Early Myocardial Infarction in Human Heart (Autopsy Study)

BACKGROUND: Many immunohistochemical markers have been used in the postmortem detection of early myocardial infarction. AIM: In the present study we examined the role of Heart-type fatty acid binding protein (H-FABP), in the detection of early myocardial infarction. MATERIAL AND METHODS: We obtained...

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Detalles Bibliográficos
Autores principales: Shabaiek, Amany, Ismael, Nour El-Hoda, Elsheikh, Samar, Amin, Hebat Allah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Institute of Immunobiology and Human Genetics 2016
Materias:
Basic Science
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4884241/
https://www.ncbi.nlm.nih.gov/pubmed/27275322
http://dx.doi.org/10.3889/oamjms.2016.018
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author Shabaiek, Amany
Ismael, Nour El-Hoda
Elsheikh, Samar
Amin, Hebat Allah
author_facet Shabaiek, Amany
Ismael, Nour El-Hoda
Elsheikh, Samar
Amin, Hebat Allah
author_sort Shabaiek, Amany
collection PubMed
description BACKGROUND: Many immunohistochemical markers have been used in the postmortem detection of early myocardial infarction. AIM: In the present study we examined the role of Heart-type fatty acid binding protein (H-FABP), in the detection of early myocardial infarction. MATERIAL AND METHODS: We obtained samples from 40 human autopsy hearts with/without histopathological signs of ischemia. RESULTS: All cases of definite and probable myocardial infarction showed a well-defined area of H-FABP depletion. All of the control cases showed strong H-FABP expression, except two markedly autolysed myocardial samples that showed affected antigenicity. CONCLUSION: Thus, we suggest H-FABP as being one of the valuable tools facing the problem of postmortem detection of early myocardial infarction/ischemia, but not in autolysis.
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spelling pubmed-48842412016-06-06 Role of Cardiac Myocytes Heart Fatty Acid Binding Protein Depletion (H-FABP) in Early Myocardial Infarction in Human Heart (Autopsy Study) Shabaiek, Amany Ismael, Nour El-Hoda Elsheikh, Samar Amin, Hebat Allah Open Access Maced J Med Sci Basic Science BACKGROUND: Many immunohistochemical markers have been used in the postmortem detection of early myocardial infarction. AIM: In the present study we examined the role of Heart-type fatty acid binding protein (H-FABP), in the detection of early myocardial infarction. MATERIAL AND METHODS: We obtained samples from 40 human autopsy hearts with/without histopathological signs of ischemia. RESULTS: All cases of definite and probable myocardial infarction showed a well-defined area of H-FABP depletion. All of the control cases showed strong H-FABP expression, except two markedly autolysed myocardial samples that showed affected antigenicity. CONCLUSION: Thus, we suggest H-FABP as being one of the valuable tools facing the problem of postmortem detection of early myocardial infarction/ischemia, but not in autolysis. Institute of Immunobiology and Human Genetics 2016-03-15 2016-01-21 /pmc/articles/PMC4884241/ /pubmed/27275322 http://dx.doi.org/10.3889/oamjms.2016.018 Text en Copyright: © 2016 Amany Shabaiek, Nour El-Hoda Ismael, Samar Elsheikh, Hebat Allah Amin. http://creativecommons.org/licenses/by/2.5/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Basic Science
Shabaiek, Amany
Ismael, Nour El-Hoda
Elsheikh, Samar
Amin, Hebat Allah
Role of Cardiac Myocytes Heart Fatty Acid Binding Protein Depletion (H-FABP) in Early Myocardial Infarction in Human Heart (Autopsy Study)
title Role of Cardiac Myocytes Heart Fatty Acid Binding Protein Depletion (H-FABP) in Early Myocardial Infarction in Human Heart (Autopsy Study)
title_full Role of Cardiac Myocytes Heart Fatty Acid Binding Protein Depletion (H-FABP) in Early Myocardial Infarction in Human Heart (Autopsy Study)
title_fullStr Role of Cardiac Myocytes Heart Fatty Acid Binding Protein Depletion (H-FABP) in Early Myocardial Infarction in Human Heart (Autopsy Study)
title_full_unstemmed Role of Cardiac Myocytes Heart Fatty Acid Binding Protein Depletion (H-FABP) in Early Myocardial Infarction in Human Heart (Autopsy Study)
title_short Role of Cardiac Myocytes Heart Fatty Acid Binding Protein Depletion (H-FABP) in Early Myocardial Infarction in Human Heart (Autopsy Study)
title_sort role of cardiac myocytes heart fatty acid binding protein depletion (h-fabp) in early myocardial infarction in human heart (autopsy study)
topic Basic Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4884241/
https://www.ncbi.nlm.nih.gov/pubmed/27275322
http://dx.doi.org/10.3889/oamjms.2016.018
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