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Analysis of cultivable microbiota and diet intake pattern of the long-lived naked mole-rat
BACKGROUND: A variety of microbial communities exist throughout the human and animal body. Genetics, environmental factors and long-term dietary habit contribute to shaping the composition of the gut microbiota. For this reason the study of the gut microbiota of a mammal exhibiting an extraordinary...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4884373/ https://www.ncbi.nlm.nih.gov/pubmed/27239229 http://dx.doi.org/10.1186/s13099-016-0107-3 |
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author | Debebe, Tewodros Holtze, Susanne Morhart, Michaela Hildebrandt, Thomas Bernd Rodewald, Steffen Huse, Klaus Platzer, Matthias Wyohannes, Dereje Yirga, Salomon Lemma, Alemayehu Thieme, Rene König, Brigitte Birkenmeier, Gerd |
author_facet | Debebe, Tewodros Holtze, Susanne Morhart, Michaela Hildebrandt, Thomas Bernd Rodewald, Steffen Huse, Klaus Platzer, Matthias Wyohannes, Dereje Yirga, Salomon Lemma, Alemayehu Thieme, Rene König, Brigitte Birkenmeier, Gerd |
author_sort | Debebe, Tewodros |
collection | PubMed |
description | BACKGROUND: A variety of microbial communities exist throughout the human and animal body. Genetics, environmental factors and long-term dietary habit contribute to shaping the composition of the gut microbiota. For this reason the study of the gut microbiota of a mammal exhibiting an extraordinary life span is of great importance. The naked mole-rat (Heterocephalus glaber) is a eusocial mammal known for its longevity and cancer resistance. METHODS: Here we analyzed its gut microbiota by cultivating the bacteria under aerobic and anaerobic conditions and identifying their species by mass spectrometry. RESULTS: Altogether, 29 species of microbes were identified, predominantly belonging to Firmicutes, and Bacteroidetes. The most frequent species were Bacillus megaterium (45.2 %), followed by Bacteroides thetaiotaomicron (19.4 %), Bacteroides ovatus, Staphylococcus sciuri and Paenibacillus spp., each with a frequency of 16.1 %. CONCLUSION: Overall, the gut of the naked mole-rat is colonized by diverse, but low numbers of cultivable microbes compared with humans and mice. The primary food plants of the rodents are rich in polyphenols and related compounds, possessing anti-microbial, anti-inflammatory, anti-oxidative as well as anti-cancer activity which may contribute to their exceptionally healthy life. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13099-016-0107-3) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-4884373 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-48843732016-05-29 Analysis of cultivable microbiota and diet intake pattern of the long-lived naked mole-rat Debebe, Tewodros Holtze, Susanne Morhart, Michaela Hildebrandt, Thomas Bernd Rodewald, Steffen Huse, Klaus Platzer, Matthias Wyohannes, Dereje Yirga, Salomon Lemma, Alemayehu Thieme, Rene König, Brigitte Birkenmeier, Gerd Gut Pathog Research BACKGROUND: A variety of microbial communities exist throughout the human and animal body. Genetics, environmental factors and long-term dietary habit contribute to shaping the composition of the gut microbiota. For this reason the study of the gut microbiota of a mammal exhibiting an extraordinary life span is of great importance. The naked mole-rat (Heterocephalus glaber) is a eusocial mammal known for its longevity and cancer resistance. METHODS: Here we analyzed its gut microbiota by cultivating the bacteria under aerobic and anaerobic conditions and identifying their species by mass spectrometry. RESULTS: Altogether, 29 species of microbes were identified, predominantly belonging to Firmicutes, and Bacteroidetes. The most frequent species were Bacillus megaterium (45.2 %), followed by Bacteroides thetaiotaomicron (19.4 %), Bacteroides ovatus, Staphylococcus sciuri and Paenibacillus spp., each with a frequency of 16.1 %. CONCLUSION: Overall, the gut of the naked mole-rat is colonized by diverse, but low numbers of cultivable microbes compared with humans and mice. The primary food plants of the rodents are rich in polyphenols and related compounds, possessing anti-microbial, anti-inflammatory, anti-oxidative as well as anti-cancer activity which may contribute to their exceptionally healthy life. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13099-016-0107-3) contains supplementary material, which is available to authorized users. BioMed Central 2016-05-28 /pmc/articles/PMC4884373/ /pubmed/27239229 http://dx.doi.org/10.1186/s13099-016-0107-3 Text en © The Author(s) 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Debebe, Tewodros Holtze, Susanne Morhart, Michaela Hildebrandt, Thomas Bernd Rodewald, Steffen Huse, Klaus Platzer, Matthias Wyohannes, Dereje Yirga, Salomon Lemma, Alemayehu Thieme, Rene König, Brigitte Birkenmeier, Gerd Analysis of cultivable microbiota and diet intake pattern of the long-lived naked mole-rat |
title | Analysis of cultivable microbiota and diet intake pattern of the long-lived naked mole-rat |
title_full | Analysis of cultivable microbiota and diet intake pattern of the long-lived naked mole-rat |
title_fullStr | Analysis of cultivable microbiota and diet intake pattern of the long-lived naked mole-rat |
title_full_unstemmed | Analysis of cultivable microbiota and diet intake pattern of the long-lived naked mole-rat |
title_short | Analysis of cultivable microbiota and diet intake pattern of the long-lived naked mole-rat |
title_sort | analysis of cultivable microbiota and diet intake pattern of the long-lived naked mole-rat |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4884373/ https://www.ncbi.nlm.nih.gov/pubmed/27239229 http://dx.doi.org/10.1186/s13099-016-0107-3 |
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