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Secretory leukocyte protease inhibitor gene deletion alters bleomycin-induced lung injury, but not development of pulmonary fibrosis

Idiopathic Pulmonary Fibrosis (IPF) is a progressive, fatal disease with limited treatment options. Protease mediated transforming growth factor-β (TGF-β) activation has been proposed as a pathogenic mechanism of lung fibrosis. Protease activity in the lung is tightly regulated by protease inhibitor...

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Detalles Bibliográficos
Autores principales:	Habgood, Anthony N, Tatler, Amanda L, Porte, Joanne, Wahl, Sharon M, Laurent, Geoffrey J, John, Alison E, Johnson, Simon R, Jenkins, Gisli
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4884449/ https://www.ncbi.nlm.nih.gov/pubmed/26974397 http://dx.doi.org/10.1038/labinvest.2016.40

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