Renal Thrombotic Microangiopathy Associated with the Use of Bortezomib in a Patient with Multiple Myeloma

Bortezomib is a first-generation proteasome inhibitor used in the treatment of multiple myeloma (MM). A few reports have linked bortezomib exposure with the development of thrombotic microangiopathy (TMA). We describe a case of biopsy-proven renal thrombotic microangiopathy associated with the use o...

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Autores principales: Van Keer, Jan, Delforge, Michel, Dierickx, Daan, Peerlinck, Kathelijne, Lerut, Evelyne, Sprangers, Ben
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4884801/
https://www.ncbi.nlm.nih.gov/pubmed/27293920
http://dx.doi.org/10.1155/2016/6020691
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author Van Keer, Jan
Delforge, Michel
Dierickx, Daan
Peerlinck, Kathelijne
Lerut, Evelyne
Sprangers, Ben
author_facet Van Keer, Jan
Delforge, Michel
Dierickx, Daan
Peerlinck, Kathelijne
Lerut, Evelyne
Sprangers, Ben
author_sort Van Keer, Jan
collection PubMed
description Bortezomib is a first-generation proteasome inhibitor used in the treatment of multiple myeloma (MM). A few reports have linked bortezomib exposure with the development of thrombotic microangiopathy (TMA). We describe a case of biopsy-proven renal thrombotic microangiopathy associated with the use of bortezomib in a 51-year-old man with IgG lambda MM. To our knowledge, this is the first biopsy-proven case. In addition, reexposure to bortezomib 18 months later was associated with recurrence of TMA. This supports a possible causal role of bortezomib. The exact mechanisms remain to be elucidated.
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spelling pubmed-48848012016-06-12 Renal Thrombotic Microangiopathy Associated with the Use of Bortezomib in a Patient with Multiple Myeloma Van Keer, Jan Delforge, Michel Dierickx, Daan Peerlinck, Kathelijne Lerut, Evelyne Sprangers, Ben Case Rep Hematol Case Report Bortezomib is a first-generation proteasome inhibitor used in the treatment of multiple myeloma (MM). A few reports have linked bortezomib exposure with the development of thrombotic microangiopathy (TMA). We describe a case of biopsy-proven renal thrombotic microangiopathy associated with the use of bortezomib in a 51-year-old man with IgG lambda MM. To our knowledge, this is the first biopsy-proven case. In addition, reexposure to bortezomib 18 months later was associated with recurrence of TMA. This supports a possible causal role of bortezomib. The exact mechanisms remain to be elucidated. Hindawi Publishing Corporation 2016 2016-05-16 /pmc/articles/PMC4884801/ /pubmed/27293920 http://dx.doi.org/10.1155/2016/6020691 Text en Copyright © 2016 Jan Van Keer et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Van Keer, Jan
Delforge, Michel
Dierickx, Daan
Peerlinck, Kathelijne
Lerut, Evelyne
Sprangers, Ben
Renal Thrombotic Microangiopathy Associated with the Use of Bortezomib in a Patient with Multiple Myeloma
title Renal Thrombotic Microangiopathy Associated with the Use of Bortezomib in a Patient with Multiple Myeloma
title_full Renal Thrombotic Microangiopathy Associated with the Use of Bortezomib in a Patient with Multiple Myeloma
title_fullStr Renal Thrombotic Microangiopathy Associated with the Use of Bortezomib in a Patient with Multiple Myeloma
title_full_unstemmed Renal Thrombotic Microangiopathy Associated with the Use of Bortezomib in a Patient with Multiple Myeloma
title_short Renal Thrombotic Microangiopathy Associated with the Use of Bortezomib in a Patient with Multiple Myeloma
title_sort renal thrombotic microangiopathy associated with the use of bortezomib in a patient with multiple myeloma
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4884801/
https://www.ncbi.nlm.nih.gov/pubmed/27293920
http://dx.doi.org/10.1155/2016/6020691
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