Spatially- and temporally-controlled postnatal p53 knockdown cooperates with embryonic Schwann cell precursor Nf1 gene loss to promote malignant peripheral nerve sheath tumor formation

Malignant peripheral nerve sheath tumors (MPNSTs) are highly aggressive sarcomas that arise sporadically or in association with the Neurofibromatosis type 1 (NF1) cancer predisposition syndrome. In individuals with NF1, MPNSTs are hypothesized to arise from Nf1-deficient Schwann cell precursor cells...

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Detalles Bibliográficos
Autores principales: Hirbe, Angela C., Dahiya, Sonika, Friedmann-Morvinski, Dinorah, Verma, Inder M., Clapp, D. Wade, Gutmann, David H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Priority Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4884927/
https://www.ncbi.nlm.nih.gov/pubmed/26859681
http://dx.doi.org/10.18632/oncotarget.7232

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4884927/
https://www.ncbi.nlm.nih.gov/pubmed/26859681
http://dx.doi.org/10.18632/oncotarget.7232

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