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Modular transcriptional repertoire and MicroRNA target analyses characterize genomic dysregulation in the thymus of Down syndrome infants
Trisomy 21-driven transcriptional alterations in human thymus were characterized through gene coexpression network (GCN) and miRNA-target analyses. We used whole thymic tissue - obtained at heart surgery from Down syndrome (DS) and karyotipically normal subjects (CT) - and a network-based approach f...
Autores principales: | Moreira-Filho, Carlos Alberto, Bando, Silvia Yumi, Bertonha, Fernanda Bernardi, Silva, Filipi Nascimento, da Fontoura Costa, Luciano, Ferreira, Leandro Rodrigues, Furlanetto, Glaucio, Chacur, Paulo, Zerbini, Maria Claudia Nogueira, Carneiro-Sampaio, Magda |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4884935/ https://www.ncbi.nlm.nih.gov/pubmed/26848775 http://dx.doi.org/10.18632/oncotarget.7120 |
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