Effectiveness and safety of poly (ADP-ribose) polymerase inhibitors in cancer therapy: A systematic review and meta-analysis

Poly (ADP-ribose) polymerase (PARP) inhibitors are a class of small-molecule drugs suppressing PARP enzymes activity, inducing the death of cells deficient in homologous recombination repair (HRR). HRR deficiency is common in tumor cells with BRCA gene mutation. Since their first clinical trial in 2...

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Detalles Bibliográficos
Autores principales: Bao, Zhengqiang, Cao, Chao, Geng, Xinwei, Tian, Baoping, Wu, Yanping, Zhang, Chao, Chen, Zhihua, Li, Wen, Shen, Huahao, Ying, Songmin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Clinical Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4884943/
https://www.ncbi.nlm.nih.gov/pubmed/26399274
http://dx.doi.org/10.18632/oncotarget.5367

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