Sonic hedgehog inhibitors prevent colitis-associated cancer via orchestrated mechanisms of IL-6/gp130 inhibition, 15-PGDH induction, Bcl-2 abrogation, and tumorsphere inhibition

Sonic hedgehog (SHH) signaling is essential in normal development of the gastrointestinal (GI) tract, whereas aberrantly activated SHH is implicated in GI cancers because it facilitates carcinogenesis by redirecting stem cells. Since colitis-associated cancer (CAC) is associated with inflammatory bo...

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Detalles Bibliográficos
Autores principales: Kangwan, Napapan, Kim, Yoon-Jae, Han, Young Min, Jeong, Migyeong, Park, Jong-Min, Go, Eun-Jin, Hahm, Ki-Baik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4884946/
https://www.ncbi.nlm.nih.gov/pubmed/26716648
http://dx.doi.org/10.18632/oncotarget.6765

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