Hypoxia-inducible factor 1 upregulation of both VEGF and ANGPTL4 is required to promote the angiogenic phenotype in uveal melanoma

PURPOSE: Expression of the hypoxia-inducible factor (HIF)-1-regulated gene product, vascular endothelial growth factor (VEGF), correlates with tumor vascularity in patients with uveal melanoma (UM). While the relationship between HIF-1 and VEGF in cancer is well-studied, their relative contribution...

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Detalles Bibliográficos
Autores principales: Hu, Ke, Babapoor-Farrokhran, Savalan, Rodrigues, Murilo, Deshpande, Monika, Puchner, Brooks, Kashiwabuchi, Fabiana, Hassan, Syed Junaid, Asnaghi, Laura, Handa, James T., Merbs, Shannath, Eberhart, Charles G., Semenza, Gregg L., Montaner, Silvia, Sodhi, Akrit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4884956/
https://www.ncbi.nlm.nih.gov/pubmed/26761211
http://dx.doi.org/10.18632/oncotarget.6868

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