Cargando…
Long lasting MDM2/Translocator protein modulator: a new strategy for irreversible apoptosis of human glioblastoma cells
The development of multi-target drugs and irreversible modulators of deregulated signalling proteins is the major challenge for improving glioblastoma multiforme (GBM) treatment. Reversible single-target drugs are not sufficient to sustain a therapeutic effect over time and may favour the activation...
Autores principales: | Daniele, Simona, Barresi, Elisabetta, Zappelli, Elisa, Marinelli, Luciana, Novellino, Ettore, Da Settimo, Federico, Taliani, Sabrina, Trincavelli, Maria L., Martini, Claudia |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4884960/ https://www.ncbi.nlm.nih.gov/pubmed/26761214 http://dx.doi.org/10.18632/oncotarget.6872 |
Ejemplares similares
-
Apoptosis Therapy in Cancer: The First Single-molecule Co-activating p53 and the Translocator Protein in Glioblastoma
por: Daniele, Simona, et al.
Publicado: (2014) -
Combined inhibition of AKT/mTOR and MDM2 enhances Glioblastoma Multiforme cell apoptosis and differentiation of cancer stem cells
por: Daniele, Simona, et al.
Publicado: (2015) -
Allosterism vs. Orthosterism: Recent Findings and Future Perspectives on A(2B) AR Physio-Pathological Implications
por: Barresi, Elisabetta, et al.
Publicado: (2021) -
Lactate dehydrogenase-A inhibition induces human glioblastoma multiforme stem cell differentiation and death
por: Daniele, Simona, et al.
Publicado: (2015) -
Target-Based Anticancer Indole Derivatives for the Development of Anti-Glioblastoma Agents
por: Salerno, Silvia, et al.
Publicado: (2023)