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Fractionation of a tumor-initiating UV dose introduces DNA damage-retaining cells in hairless mouse skin and renders subsequent TPA-promoted tumors non-regressing
Sunburns and especially sub-sunburn chronic UV exposure are associated with increased risk of squamous cell carcinomas (SCCs). Here we focus on a possible difference in tumor initiation from a single severe-sunburn dose (on day 1, 21 hairless mice) and from an equal dose fractionated into very low s...
Autores principales: | van de Glind, Gerline, Rebel, Heggert, van Kempen, Marika, Tensen, Kees, de Gruijl, Frank |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4884976/ https://www.ncbi.nlm.nih.gov/pubmed/26797757 http://dx.doi.org/10.18632/oncotarget.6932 |
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