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CTNNA3 is a tumor suppressor in hepatocellular carcinomas and is inhibited by miR-425

Hepatocellular carcinoma (HCC) is a common and leading cause of death worldwide. Here, we identified that a cell-cell adhesion gene, CTNNA3, is a tumor suppressor in HCC. CTNNA3 inhibited the proliferation, migration and invasion of HCC cell lines. In these cells, CTNNA3 inhibited Akt signal, and in...

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Autores principales: He, Bing, Li, Ting, Guan, Lei, Liu, Fang-E, Chen, Xue-Mei, Zhao, Jing, Lin, Song, Liu, Zhi-Zhen, Zhang, Hu-Qin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4884977/
https://www.ncbi.nlm.nih.gov/pubmed/26882563
http://dx.doi.org/10.18632/oncotarget.6978
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author He, Bing
Li, Ting
Guan, Lei
Liu, Fang-E
Chen, Xue-Mei
Zhao, Jing
Lin, Song
Liu, Zhi-Zhen
Zhang, Hu-Qin
author_facet He, Bing
Li, Ting
Guan, Lei
Liu, Fang-E
Chen, Xue-Mei
Zhao, Jing
Lin, Song
Liu, Zhi-Zhen
Zhang, Hu-Qin
author_sort He, Bing
collection PubMed
description Hepatocellular carcinoma (HCC) is a common and leading cause of death worldwide. Here, we identified that a cell-cell adhesion gene, CTNNA3, is a tumor suppressor in HCC. CTNNA3 inhibited the proliferation, migration and invasion of HCC cell lines. In these cells, CTNNA3 inhibited Akt signal, and in turn decreased the proliferating cell nuclear antigen (PCNA) and the matrix metallopeptidase MMP-9, and increased the cell cycle inhibitor p21(Cip1/Waf1). Meanwhile, CTNNA3 is inhibited by miR-425 in HCC. The miR-425 directly bound to the 3′UTR of CTNNA3 and inhibited its expression. The tumor suppressor function of CTNNA3 and the oncogenic function of miR-425 were further confirmed in HCC cell xenograft in nude mice. The miR-425/CTNNA3 axis may provide insights into the mechanisms underlying HCC, and contribute to potential therapeutic strategy of HCC.
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spelling pubmed-48849772016-06-17 CTNNA3 is a tumor suppressor in hepatocellular carcinomas and is inhibited by miR-425 He, Bing Li, Ting Guan, Lei Liu, Fang-E Chen, Xue-Mei Zhao, Jing Lin, Song Liu, Zhi-Zhen Zhang, Hu-Qin Oncotarget Research Paper Hepatocellular carcinoma (HCC) is a common and leading cause of death worldwide. Here, we identified that a cell-cell adhesion gene, CTNNA3, is a tumor suppressor in HCC. CTNNA3 inhibited the proliferation, migration and invasion of HCC cell lines. In these cells, CTNNA3 inhibited Akt signal, and in turn decreased the proliferating cell nuclear antigen (PCNA) and the matrix metallopeptidase MMP-9, and increased the cell cycle inhibitor p21(Cip1/Waf1). Meanwhile, CTNNA3 is inhibited by miR-425 in HCC. The miR-425 directly bound to the 3′UTR of CTNNA3 and inhibited its expression. The tumor suppressor function of CTNNA3 and the oncogenic function of miR-425 were further confirmed in HCC cell xenograft in nude mice. The miR-425/CTNNA3 axis may provide insights into the mechanisms underlying HCC, and contribute to potential therapeutic strategy of HCC. Impact Journals LLC 2016-01-22 /pmc/articles/PMC4884977/ /pubmed/26882563 http://dx.doi.org/10.18632/oncotarget.6978 Text en Copyright: © 2016 He et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
He, Bing
Li, Ting
Guan, Lei
Liu, Fang-E
Chen, Xue-Mei
Zhao, Jing
Lin, Song
Liu, Zhi-Zhen
Zhang, Hu-Qin
CTNNA3 is a tumor suppressor in hepatocellular carcinomas and is inhibited by miR-425
title CTNNA3 is a tumor suppressor in hepatocellular carcinomas and is inhibited by miR-425
title_full CTNNA3 is a tumor suppressor in hepatocellular carcinomas and is inhibited by miR-425
title_fullStr CTNNA3 is a tumor suppressor in hepatocellular carcinomas and is inhibited by miR-425
title_full_unstemmed CTNNA3 is a tumor suppressor in hepatocellular carcinomas and is inhibited by miR-425
title_short CTNNA3 is a tumor suppressor in hepatocellular carcinomas and is inhibited by miR-425
title_sort ctnna3 is a tumor suppressor in hepatocellular carcinomas and is inhibited by mir-425
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4884977/
https://www.ncbi.nlm.nih.gov/pubmed/26882563
http://dx.doi.org/10.18632/oncotarget.6978
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