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Structural Analysis of dsRNA Binding to Anti-viral Pattern Recognition Receptors LGP2 and MDA5

RIG-I and MDA5 sense virus-derived short 5′ppp blunt-ended or long dsRNA, respectively, causing interferon production. Non-signaling LGP2 appears to positively and negatively regulate MDA5 and RIG-I signaling, respectively. Co-crystal structures of chicken (ch) LGP2 with dsRNA display a fully or sem...

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Detalles Bibliográficos
Autores principales:	Uchikawa, Emiko, Lethier, Mathilde, Malet, Hélène, Brunel, Joanna, Gerlier, Denis, Cusack, Stephen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4885022/ https://www.ncbi.nlm.nih.gov/pubmed/27203181 http://dx.doi.org/10.1016/j.molcel.2016.04.021

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