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The Spider Venom Peptide Lycosin-II Has Potent Antimicrobial Activity against Clinically Isolated Bacteria
Antimicrobial peptides have been accepted as excellent candidates for developing novel antibiotics against drug-resistant bacteria. Recent studies indicate that spider venoms are the source for the identification of novel antimicrobial peptides. In the present study, we isolated and characterized an...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4885036/ https://www.ncbi.nlm.nih.gov/pubmed/27128941 http://dx.doi.org/10.3390/toxins8050119 |
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author | Wang, Yongjun Wang, Ling Yang, Huali Xiao, Haoliang Farooq, Athar Liu, Zhonghua Hu, Min Shi, Xiaoliu |
author_facet | Wang, Yongjun Wang, Ling Yang, Huali Xiao, Haoliang Farooq, Athar Liu, Zhonghua Hu, Min Shi, Xiaoliu |
author_sort | Wang, Yongjun |
collection | PubMed |
description | Antimicrobial peptides have been accepted as excellent candidates for developing novel antibiotics against drug-resistant bacteria. Recent studies indicate that spider venoms are the source for the identification of novel antimicrobial peptides. In the present study, we isolated and characterized an antibacterial peptide named lycosin-II from the venom of the spider Lycosa singoriensis. It contains 21 amino acid residue lacking cysteine residues and forms a typical linear amphipathic and cationic α-helical conformation. Lycosin-II displays potent bacteriostatic effect on the tested drug-resistant bacterial strains isolated from hospital patients, including multidrug-resistant A. baumannii, which has presented a huge challenge for the infection therapy. The inhibitory ability of lycosin-II might derive from its binding to cell membrane, because Mg(2+) could compete with the binding sites to reduce the bacteriostatic potency of lycosin-II. Our data suggest that lycosin-II might be a lead in the development of novel antibiotics for curing drug-resistant bacterial infections. |
format | Online Article Text |
id | pubmed-4885036 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-48850362016-05-31 The Spider Venom Peptide Lycosin-II Has Potent Antimicrobial Activity against Clinically Isolated Bacteria Wang, Yongjun Wang, Ling Yang, Huali Xiao, Haoliang Farooq, Athar Liu, Zhonghua Hu, Min Shi, Xiaoliu Toxins (Basel) Article Antimicrobial peptides have been accepted as excellent candidates for developing novel antibiotics against drug-resistant bacteria. Recent studies indicate that spider venoms are the source for the identification of novel antimicrobial peptides. In the present study, we isolated and characterized an antibacterial peptide named lycosin-II from the venom of the spider Lycosa singoriensis. It contains 21 amino acid residue lacking cysteine residues and forms a typical linear amphipathic and cationic α-helical conformation. Lycosin-II displays potent bacteriostatic effect on the tested drug-resistant bacterial strains isolated from hospital patients, including multidrug-resistant A. baumannii, which has presented a huge challenge for the infection therapy. The inhibitory ability of lycosin-II might derive from its binding to cell membrane, because Mg(2+) could compete with the binding sites to reduce the bacteriostatic potency of lycosin-II. Our data suggest that lycosin-II might be a lead in the development of novel antibiotics for curing drug-resistant bacterial infections. MDPI 2016-04-26 /pmc/articles/PMC4885036/ /pubmed/27128941 http://dx.doi.org/10.3390/toxins8050119 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Wang, Yongjun Wang, Ling Yang, Huali Xiao, Haoliang Farooq, Athar Liu, Zhonghua Hu, Min Shi, Xiaoliu The Spider Venom Peptide Lycosin-II Has Potent Antimicrobial Activity against Clinically Isolated Bacteria |
title | The Spider Venom Peptide Lycosin-II Has Potent Antimicrobial Activity against Clinically Isolated Bacteria |
title_full | The Spider Venom Peptide Lycosin-II Has Potent Antimicrobial Activity against Clinically Isolated Bacteria |
title_fullStr | The Spider Venom Peptide Lycosin-II Has Potent Antimicrobial Activity against Clinically Isolated Bacteria |
title_full_unstemmed | The Spider Venom Peptide Lycosin-II Has Potent Antimicrobial Activity against Clinically Isolated Bacteria |
title_short | The Spider Venom Peptide Lycosin-II Has Potent Antimicrobial Activity against Clinically Isolated Bacteria |
title_sort | spider venom peptide lycosin-ii has potent antimicrobial activity against clinically isolated bacteria |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4885036/ https://www.ncbi.nlm.nih.gov/pubmed/27128941 http://dx.doi.org/10.3390/toxins8050119 |
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