Cargando…

Re-Designed Recombinant Hepatitis B Virus Vectors Enable Efficient Delivery of Versatile Cargo Genes to Hepatocytes with Improved Safety

Hepatitis B virus (HBV) takes humans as its sole natural host, and productive infection in vivo is restricted exclusively to hepatocytes in the liver. Consequently, HBV-derived viral vectors are attractive candidates for liver-targeting gene therapies. Previously, we developed a novel recombinant HB...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bai, Weiya, Cui, Xiaoxian, Chen, Ruidong, Tao, Shuai, Hong, Ran, Zhang, Jiming, Zhang, Junqi, Wang, Yongxiang, Xie, Youhua, Liu, Jing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4885084/ https://www.ncbi.nlm.nih.gov/pubmed/27171107 http://dx.doi.org/10.3390/v8050129

Ejemplares similares

Engineering Hepadnaviruses as Reporter-Expressing Vectors: Recent Progress and Future Perspectives
por: Bai, Weiya, et al.
Publicado: (2016)

Versatile Loading of Diverse Cargo into Functional Polymer Capsules
por: Richardson, Joseph J., et al.
Publicado: (2015)

Synergistic Cytotoxicity of Lenalidomide and Dexamethasone in Mantle Cell Lymphoma via Cereblon-dependent Targeting of the IL-6/STAT3/PI3K Axis
por: Ma, Jiexian, et al.
Publicado: (2017)

Hepatocyte nuclear factor 1α downregulates HBV gene expression and replication by activating the NF-κB signaling pathway
por: Lin, Junyu, et al.
Publicado: (2017)

Improving Salmonella vector with rec mutation to stabilize the DNA cargoes
por: Zhang, Xiangmin, et al.
Publicado: (2011)

Short-term intratracheal use of PEG-modified IL-2 and glucocorticoid persistently alleviates asthma in a mouse model
por: Wu, Kefei, et al.
Publicado: (2016)

Azide click chemistry on magnetotactic bacteria: A versatile technique to attach a cargo
por: David Soto Rodriguez, Paul Eduardo, et al.
Publicado: (2023)

Improved dsDNA recombineering enables versatile multiplex genome engineering of kilobase-scale sequences in diverse bacteria
por: Wang, Xue, et al.
Publicado: (2021)

Uptake, functionality, and re-release of extracellular vesicle-encapsulated cargo
por: O’Brien, Killian, et al.
Publicado: (2022)

Hepatitis B virus X protein is capable of down-regulating protein level of host antiviral protein APOBEC3G
por: Chen, Ruidong, et al.
Publicado: (2017)

Hepatitis B virus persistence in mice reveals IL-21 and IL-33 as regulators of viral clearance
por: Shen, Zhongliang, et al.
Publicado: (2017)

Identification and characterization of highly versatile peptide-vectors that bind non-competitively to the low-density lipoprotein receptor for in vivo targeting and delivery of small molecules and protein cargos
por: David, Marion, et al.
Publicado: (2018)

Efficient Inhibition of Hepatitis B Virus Infection by a preS1-binding Peptide
por: Ye, Xiaoli, et al.
Publicado: (2016)

Broadening the versatility of lentiviral vectors as a tool in nucleic acid research via genetic code expansion
por: Zheng, Yongxiang, et al.
Publicado: (2015)

A versatile cell-penetrating peptide-adaptor system for efficient delivery of molecular cargos to subcellular destinations
por: Ngwa, Verra M., et al.
Publicado: (2017)

Comparative Transcriptomic Analysis of Primary Duck Hepatocytes Provides Insight into Differential Susceptibility to DHBV Infection
por: Yan, Liang, et al.
Publicado: (2016)

The pMy vector series: A versatile cloning platform for the recombinant production of mycobacterial proteins in Mycobacterium smegmatis
por: Beckham, Katherine S. H., et al.
Publicado: (2020)

A recombinant BBSome core complex and how it interacts with ciliary cargo
por: Klink, Björn Udo, et al.
Publicado: (2017)

Development of Versatile Vectors for Heterologous Expression in Bacillus
por: Larsen, Øivind, et al.
Publicado: (2018)

Polymer Capsules: Versatile Loading of Diverse Cargo into Functional Polymer Capsules (Adv. Sci. 1‐2/2015)
por: Richardson, Joseph J., et al.
Publicado: (2015)

Targeted delivery of nanomaterials with chemical cargoes in plants enabled by a biorecognition motif
por: Santana, Israel, et al.
Publicado: (2020)

A versatile platform technology for recombinant vaccines using non-propagative human parainfluenza virus type 2 vector
por: Ohtsuka, Junpei, et al.
Publicado: (2019)

A Versatile Vector Toolkit for Functional Analysis of Rice Genes
por: He, Feng, et al.
Publicado: (2018)

Flagellum-driven cargoes: Influence of cargo size and the flagellum-cargo attachment geometry
por: Bae, Albert J., et al.
Publicado: (2023)

Recent Advances of Cell-Penetrating Peptides and Their Application as Vectors for Delivery of Peptide and Protein-Based Cargo Molecules
por: Zhang, Huifeng, et al.
Publicado: (2023)

Implementing Cargo Movement into Climate Based Risk Assessment of Vector-Borne Diseases
por: Thomas, Stephanie Margarete, et al.
Publicado: (2014)

Improved Acid Resistance of a Metal–Organic Cage Enables Cargo Release and Exchange between Hosts
por: Xu, Lin, et al.
Publicado: (2020)

Tunable DNA Hybridization Enables Spatially and Temporally Controlled Surface-Anchoring of Biomolecular Cargo
por: Hager, Roland, et al.
Publicado: (2018)

All-in-one disulfide bridging enables the generation of antibody conjugates with modular cargo loading
por: Dannheim, Friederike M., et al.
Publicado: (2022)

Correction to: A Versatile Vector Toolkit for Functional Analysis of Rice Genes
por: He, Feng, et al.
Publicado: (2018)

Antigen-selective modulation of AAV immunogenicity with tolerogenic rapamycin nanoparticles enables successful vector re-administration
por: Meliani, Amine, et al.
Publicado: (2018)

Applications and Challenges for Use of Cell-Penetrating Peptides as Delivery Vectors for Peptide and Protein Cargos
por: Kristensen, Mie, et al.
Publicado: (2016)

A versatile, efficient strategy for assembly of multi-fragment expression vectors in Saccharomyces cerevisiae using 60 bp synthetic recombination sequences
por: Kuijpers, Niels GA, et al.
Publicado: (2013)

retro-Tango enables versatile retrograde circuit tracing in Drosophila
por: Sorkaç, Altar, et al.
Publicado: (2023)

The tunable pReX expression vector enables optimizing the T7-based production of membrane and secretory proteins in E. coli
por: Kuipers, Grietje, et al.
Publicado: (2017)

Cargo Crime
por: Coughlin, John
Publicado: (2012)

Re-engineering an alphoid(tetO)-HAC-based vector to enable high-throughput analyses of gene function
por: Kononenko, Artem V., et al.
Publicado: (2013)

Milk-derived exosomes exhibit versatile effects for improved oral drug delivery
por: Wu, Lei, et al.
Publicado: (2022)

Tol2: a versatile gene transfer vector in vertebrates
por: Kawakami, Koichi
Publicado: (2007)

Baculovirus as versatile vectors for protein expression in insect and mammalian cells
por: Kost, Thomas A, et al.
Publicado: (2005)

Cannot write session to /tmp/vufind_sessions/sess_uctvsbsuhu1ukgt6jnb449l7td