Use of Reporter Genes in the Generation of Vaccinia Virus-Derived Vectors

Vaccinia virus (VACV) is one of the most extensively-studied viruses of the Poxviridae family. It is easy to genetically modify, so it has become a key tool for many applications. In this context, reporter genes facilitate the study of the role of foreign genes introduced into the genome of VACV. In...

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Detalles Bibliográficos
Autores principales: Al Ali, Sally, Baldanta, Sara, Fernández-Escobar, Mercedes, Guerra, Susana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4885089/
https://www.ncbi.nlm.nih.gov/pubmed/27213433
http://dx.doi.org/10.3390/v8050134
Descripción
Sumario:Vaccinia virus (VACV) is one of the most extensively-studied viruses of the Poxviridae family. It is easy to genetically modify, so it has become a key tool for many applications. In this context, reporter genes facilitate the study of the role of foreign genes introduced into the genome of VACV. In this review, we describe the type of reporter genes that have been used to generate reporter-expressing VACV and the applications of the recombinant viruses obtained. Reporter-expressing VACV are currently employed in basic and immunology research, in the development of vaccines and cancer treatment.

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