Use of Reporter Genes in the Generation of Vaccinia Virus-Derived Vectors

Vaccinia virus (VACV) is one of the most extensively-studied viruses of the Poxviridae family. It is easy to genetically modify, so it has become a key tool for many applications. In this context, reporter genes facilitate the study of the role of foreign genes introduced into the genome of VACV. In...

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Detalles Bibliográficos
Autores principales: Al Ali, Sally, Baldanta, Sara, Fernández-Escobar, Mercedes, Guerra, Susana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4885089/
https://www.ncbi.nlm.nih.gov/pubmed/27213433
http://dx.doi.org/10.3390/v8050134
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author Al Ali, Sally
Baldanta, Sara
Fernández-Escobar, Mercedes
Guerra, Susana
author_facet Al Ali, Sally
Baldanta, Sara
Fernández-Escobar, Mercedes
Guerra, Susana
author_sort Al Ali, Sally
collection PubMed
description Vaccinia virus (VACV) is one of the most extensively-studied viruses of the Poxviridae family. It is easy to genetically modify, so it has become a key tool for many applications. In this context, reporter genes facilitate the study of the role of foreign genes introduced into the genome of VACV. In this review, we describe the type of reporter genes that have been used to generate reporter-expressing VACV and the applications of the recombinant viruses obtained. Reporter-expressing VACV are currently employed in basic and immunology research, in the development of vaccines and cancer treatment.
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spelling pubmed-48850892016-05-31 Use of Reporter Genes in the Generation of Vaccinia Virus-Derived Vectors Al Ali, Sally Baldanta, Sara Fernández-Escobar, Mercedes Guerra, Susana Viruses Review Vaccinia virus (VACV) is one of the most extensively-studied viruses of the Poxviridae family. It is easy to genetically modify, so it has become a key tool for many applications. In this context, reporter genes facilitate the study of the role of foreign genes introduced into the genome of VACV. In this review, we describe the type of reporter genes that have been used to generate reporter-expressing VACV and the applications of the recombinant viruses obtained. Reporter-expressing VACV are currently employed in basic and immunology research, in the development of vaccines and cancer treatment. MDPI 2016-05-21 /pmc/articles/PMC4885089/ /pubmed/27213433 http://dx.doi.org/10.3390/v8050134 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Al Ali, Sally
Baldanta, Sara
Fernández-Escobar, Mercedes
Guerra, Susana
Use of Reporter Genes in the Generation of Vaccinia Virus-Derived Vectors
title Use of Reporter Genes in the Generation of Vaccinia Virus-Derived Vectors
title_full Use of Reporter Genes in the Generation of Vaccinia Virus-Derived Vectors
title_fullStr Use of Reporter Genes in the Generation of Vaccinia Virus-Derived Vectors
title_full_unstemmed Use of Reporter Genes in the Generation of Vaccinia Virus-Derived Vectors
title_short Use of Reporter Genes in the Generation of Vaccinia Virus-Derived Vectors
title_sort use of reporter genes in the generation of vaccinia virus-derived vectors
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4885089/
https://www.ncbi.nlm.nih.gov/pubmed/27213433
http://dx.doi.org/10.3390/v8050134
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