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Effect of Tamoxifen and Lithium on Treatment of Acute Mania Symptoms in Children and Adolescents

OBJECTIVE: Many studies have supported the role of protein kinase C (PKC) inhibitors in the physiopathology and treatment of bipolar disorder in adults. Tamoxifen is one of the drugs with the effect of PKC inhibition. This study aimed to determine the effect of tamoxifen on the rate of improvement m...

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Autores principales: Fallah, Elham, Arman, Sorror, Najafi, Mostafa, Shayegh, Bahar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shahid Beheshti University of Medical Sciences 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4885151/
https://www.ncbi.nlm.nih.gov/pubmed/27247580
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author Fallah, Elham
Arman, Sorror
Najafi, Mostafa
Shayegh, Bahar
author_facet Fallah, Elham
Arman, Sorror
Najafi, Mostafa
Shayegh, Bahar
author_sort Fallah, Elham
collection PubMed
description OBJECTIVE: Many studies have supported the role of protein kinase C (PKC) inhibitors in the physiopathology and treatment of bipolar disorder in adults. Tamoxifen is one of the drugs with the effect of PKC inhibition. This study aimed to determine the effect of tamoxifen on the rate of improvement mania symptoms in the sample of children and adolescents with acute mania. MATERIALS & METHODS: In this randomized, placebo-controlled clinical trial study, registered in www.irct.ir with the code of IRCT201410126418N3, overall 44 patients with bipolar disorder with acute manic episode were randomly assigned into treatment and control groups. The serum levels of lithium and tamoxifen among the participants in the treatment groups were 0.8 -1.1 mg and 20-40 mg per day respectively. Serum level of lithium among participants in the control group was similar. The main comparisons were made based on the Young Mania Rating Scale (YMRS) and Children Depression Inventory (CDI) scores of the participants at baseline and at the end of each study week. The pharmacological side effects of serum level of lithium were examined weekly. Analysis of Covariance(ANCOVA) test was used for the statistical analysis. RESULTS: There was no difference in the baseline score of YMRS and CDI in the treatment and control groups while a statistical significant difference (P < 0.05) in these scores was found between and within the groups. CONCLUSION: The addition of tamoxifen to lithium causes a significant difference in reducing the symptoms of mania and depression in the treatment group compared to the control group.
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spelling pubmed-48851512016-06-01 Effect of Tamoxifen and Lithium on Treatment of Acute Mania Symptoms in Children and Adolescents Fallah, Elham Arman, Sorror Najafi, Mostafa Shayegh, Bahar Iran J Child Neurol Original Article OBJECTIVE: Many studies have supported the role of protein kinase C (PKC) inhibitors in the physiopathology and treatment of bipolar disorder in adults. Tamoxifen is one of the drugs with the effect of PKC inhibition. This study aimed to determine the effect of tamoxifen on the rate of improvement mania symptoms in the sample of children and adolescents with acute mania. MATERIALS & METHODS: In this randomized, placebo-controlled clinical trial study, registered in www.irct.ir with the code of IRCT201410126418N3, overall 44 patients with bipolar disorder with acute manic episode were randomly assigned into treatment and control groups. The serum levels of lithium and tamoxifen among the participants in the treatment groups were 0.8 -1.1 mg and 20-40 mg per day respectively. Serum level of lithium among participants in the control group was similar. The main comparisons were made based on the Young Mania Rating Scale (YMRS) and Children Depression Inventory (CDI) scores of the participants at baseline and at the end of each study week. The pharmacological side effects of serum level of lithium were examined weekly. Analysis of Covariance(ANCOVA) test was used for the statistical analysis. RESULTS: There was no difference in the baseline score of YMRS and CDI in the treatment and control groups while a statistical significant difference (P < 0.05) in these scores was found between and within the groups. CONCLUSION: The addition of tamoxifen to lithium causes a significant difference in reducing the symptoms of mania and depression in the treatment group compared to the control group. Shahid Beheshti University of Medical Sciences 2016 /pmc/articles/PMC4885151/ /pubmed/27247580 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Fallah, Elham
Arman, Sorror
Najafi, Mostafa
Shayegh, Bahar
Effect of Tamoxifen and Lithium on Treatment of Acute Mania Symptoms in Children and Adolescents
title Effect of Tamoxifen and Lithium on Treatment of Acute Mania Symptoms in Children and Adolescents
title_full Effect of Tamoxifen and Lithium on Treatment of Acute Mania Symptoms in Children and Adolescents
title_fullStr Effect of Tamoxifen and Lithium on Treatment of Acute Mania Symptoms in Children and Adolescents
title_full_unstemmed Effect of Tamoxifen and Lithium on Treatment of Acute Mania Symptoms in Children and Adolescents
title_short Effect of Tamoxifen and Lithium on Treatment of Acute Mania Symptoms in Children and Adolescents
title_sort effect of tamoxifen and lithium on treatment of acute mania symptoms in children and adolescents
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4885151/
https://www.ncbi.nlm.nih.gov/pubmed/27247580
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