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Hepatic macrophages in liver fibrosis: pathogenesis and potential therapeutic targets
Hepatic macrophages account for the largest non-parenchymal cell population in the liver. Recent studies have found that hepatic macrophages have different functions in different stages of experimental liver fibrosis. Some studies found that there are different types of hepatic macrophages in the li...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4885270/ https://www.ncbi.nlm.nih.gov/pubmed/27252881 http://dx.doi.org/10.1136/bmjgast-2016-000079 |
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author | Li, Hai You, Hong Fan, Xu Jia, Jidong |
author_facet | Li, Hai You, Hong Fan, Xu Jia, Jidong |
author_sort | Li, Hai |
collection | PubMed |
description | Hepatic macrophages account for the largest non-parenchymal cell population in the liver. Recent studies have found that hepatic macrophages have different functions in different stages of experimental liver fibrosis. Some studies found that there are different types of hepatic macrophages in the liver, although others have suggested that hepatic macrophages could switch to different phenotypes in different environments. Many studies demonstrated that while hepatic macrophages promoted fibrosis through the recruitment of proinflammatory immune cells, and the secretion of proinflammatory cytokines and chemokines in the early stages, these also promoted the resolution of hepatic fibrosis through the secretion of matrix metalloproteinases in the late stages. This article will review the current role played by hepatic macrophages in liver fibrosis and the potential therapeutic targets that modulate hepatic macrophages. |
format | Online Article Text |
id | pubmed-4885270 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-48852702016-06-01 Hepatic macrophages in liver fibrosis: pathogenesis and potential therapeutic targets Li, Hai You, Hong Fan, Xu Jia, Jidong BMJ Open Gastroenterol Review Hepatic macrophages account for the largest non-parenchymal cell population in the liver. Recent studies have found that hepatic macrophages have different functions in different stages of experimental liver fibrosis. Some studies found that there are different types of hepatic macrophages in the liver, although others have suggested that hepatic macrophages could switch to different phenotypes in different environments. Many studies demonstrated that while hepatic macrophages promoted fibrosis through the recruitment of proinflammatory immune cells, and the secretion of proinflammatory cytokines and chemokines in the early stages, these also promoted the resolution of hepatic fibrosis through the secretion of matrix metalloproteinases in the late stages. This article will review the current role played by hepatic macrophages in liver fibrosis and the potential therapeutic targets that modulate hepatic macrophages. BMJ Publishing Group 2016-05-25 /pmc/articles/PMC4885270/ /pubmed/27252881 http://dx.doi.org/10.1136/bmjgast-2016-000079 Text en Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/ This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
spellingShingle | Review Li, Hai You, Hong Fan, Xu Jia, Jidong Hepatic macrophages in liver fibrosis: pathogenesis and potential therapeutic targets |
title | Hepatic macrophages in liver fibrosis: pathogenesis and potential therapeutic targets |
title_full | Hepatic macrophages in liver fibrosis: pathogenesis and potential therapeutic targets |
title_fullStr | Hepatic macrophages in liver fibrosis: pathogenesis and potential therapeutic targets |
title_full_unstemmed | Hepatic macrophages in liver fibrosis: pathogenesis and potential therapeutic targets |
title_short | Hepatic macrophages in liver fibrosis: pathogenesis and potential therapeutic targets |
title_sort | hepatic macrophages in liver fibrosis: pathogenesis and potential therapeutic targets |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4885270/ https://www.ncbi.nlm.nih.gov/pubmed/27252881 http://dx.doi.org/10.1136/bmjgast-2016-000079 |
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