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Switching between thienopyridines in patients with acute myocardial infarction and quality of care
OBJECTIVE: In acute coronary syndromes, switching between thienopyridines is frequent. The aims of the study were to assess the association between switching practices and quality of care. METHODS: Registry study performed in 213 French public university, public non-academic and private hospitals. A...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BMJ Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4885463/ https://www.ncbi.nlm.nih.gov/pubmed/27252877 http://dx.doi.org/10.1136/openhrt-2015-000384 |
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author | Schiele, Francois Puymirat, Etienne Bonello, Laurent Meneveau, Nicolas Collet, Jean-Philippe Motreff, Pascal Ravan, Ramin Leclercq, Florence Ennezat, Pierre-Vladimir Ferrières, Jean Simon, Tabassome Danchin, Nicolas |
author_facet | Schiele, Francois Puymirat, Etienne Bonello, Laurent Meneveau, Nicolas Collet, Jean-Philippe Motreff, Pascal Ravan, Ramin Leclercq, Florence Ennezat, Pierre-Vladimir Ferrières, Jean Simon, Tabassome Danchin, Nicolas |
author_sort | Schiele, Francois |
collection | PubMed |
description | OBJECTIVE: In acute coronary syndromes, switching between thienopyridines is frequent. The aims of the study were to assess the association between switching practices and quality of care. METHODS: Registry study performed in 213 French public university, public non-academic and private hospitals. All consecutive patients admitted for acute myocardial infarction (MI; <48 hours) between 1/10/2010 and 30/11/2010 were eligible. Clinical and biological data were recorded up to 12 months follow-up. RESULTS: Among 4101 patients receiving thienopyridines, a switch was performed in 868 (21.2%): 678 (16.5%) from clopidogrel to prasugrel and 190 (4.6%) from prasugrel to clopidogrel. Predictors of switch were ST segment elevation MI presentation, admission to a cardiology unit, previous percutaneous coronary intervention, younger age, body weight >60 kg, no history of stroke, cardiac arrest, anaemia or renal dysfunction. In patients with a switch, eligibility for prasugrel was >82% and appropriate use of a switch was 86% from clopidogrel to prasugrel and 20% from prasugrel to clopidogrel. Quality indicators scored higher in the group with a switch and also in centres where the switch rate was higher. CONCLUSIONS: As applied in the French Registry on Acute ST-elevation and non ST-elevation Myocardial Infarction (FAST-MI) registry, switching from one P2Y12 inhibitor to another led to a more appropriate prescription and was associated with higher scores on indicators of quality of care. |
format | Online Article Text |
id | pubmed-4885463 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-48854632016-06-01 Switching between thienopyridines in patients with acute myocardial infarction and quality of care Schiele, Francois Puymirat, Etienne Bonello, Laurent Meneveau, Nicolas Collet, Jean-Philippe Motreff, Pascal Ravan, Ramin Leclercq, Florence Ennezat, Pierre-Vladimir Ferrières, Jean Simon, Tabassome Danchin, Nicolas Open Heart Interventional Cardiology OBJECTIVE: In acute coronary syndromes, switching between thienopyridines is frequent. The aims of the study were to assess the association between switching practices and quality of care. METHODS: Registry study performed in 213 French public university, public non-academic and private hospitals. All consecutive patients admitted for acute myocardial infarction (MI; <48 hours) between 1/10/2010 and 30/11/2010 were eligible. Clinical and biological data were recorded up to 12 months follow-up. RESULTS: Among 4101 patients receiving thienopyridines, a switch was performed in 868 (21.2%): 678 (16.5%) from clopidogrel to prasugrel and 190 (4.6%) from prasugrel to clopidogrel. Predictors of switch were ST segment elevation MI presentation, admission to a cardiology unit, previous percutaneous coronary intervention, younger age, body weight >60 kg, no history of stroke, cardiac arrest, anaemia or renal dysfunction. In patients with a switch, eligibility for prasugrel was >82% and appropriate use of a switch was 86% from clopidogrel to prasugrel and 20% from prasugrel to clopidogrel. Quality indicators scored higher in the group with a switch and also in centres where the switch rate was higher. CONCLUSIONS: As applied in the French Registry on Acute ST-elevation and non ST-elevation Myocardial Infarction (FAST-MI) registry, switching from one P2Y12 inhibitor to another led to a more appropriate prescription and was associated with higher scores on indicators of quality of care. BMJ Publishing Group 2016-05-23 /pmc/articles/PMC4885463/ /pubmed/27252877 http://dx.doi.org/10.1136/openhrt-2015-000384 Text en Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/ This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
spellingShingle | Interventional Cardiology Schiele, Francois Puymirat, Etienne Bonello, Laurent Meneveau, Nicolas Collet, Jean-Philippe Motreff, Pascal Ravan, Ramin Leclercq, Florence Ennezat, Pierre-Vladimir Ferrières, Jean Simon, Tabassome Danchin, Nicolas Switching between thienopyridines in patients with acute myocardial infarction and quality of care |
title | Switching between thienopyridines in patients with acute myocardial infarction and quality of care |
title_full | Switching between thienopyridines in patients with acute myocardial infarction and quality of care |
title_fullStr | Switching between thienopyridines in patients with acute myocardial infarction and quality of care |
title_full_unstemmed | Switching between thienopyridines in patients with acute myocardial infarction and quality of care |
title_short | Switching between thienopyridines in patients with acute myocardial infarction and quality of care |
title_sort | switching between thienopyridines in patients with acute myocardial infarction and quality of care |
topic | Interventional Cardiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4885463/ https://www.ncbi.nlm.nih.gov/pubmed/27252877 http://dx.doi.org/10.1136/openhrt-2015-000384 |
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