Prediction of Drug-Drug Interactions Arising from CYP3A induction Using a Physiologically Based Dynamic Model

Using physiologically based pharmacokinetic modeling, we predicted the magnitude of drug-drug interactions (DDIs) for studies with rifampicin and seven CYP3A4 probe substrates administered i.v. (10 studies) or orally (19 studies). The results showed a tendency to underpredict the DDI magnitude when...

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Detalles Bibliográficos
Autores principales: Almond, Lisa M., Mukadam, Sophie, Gardner, Iain, Okialda, Krystle, Wong, Susan, Hatley, Oliver, Tay, Suzanne, Rowland-Yeo, Karen, Jamei, Masoud, Rostami-Hodjegan, Amin, Kenny, Jane R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Pharmacology and Experimental Therapeutics 2016
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4885489/
https://www.ncbi.nlm.nih.gov/pubmed/27026679
http://dx.doi.org/10.1124/dmd.115.066845

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4885489/
https://www.ncbi.nlm.nih.gov/pubmed/27026679
http://dx.doi.org/10.1124/dmd.115.066845

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