Cargando…

Assessing Colonic Exposure, Safety, and Clinical Activity of SRT2104, a Novel Oral SIRT1 Activator, in Patients with Mild to Moderate Ulcerative Colitis

BACKGROUND: Sirtuins are a class of proteins with important physiologic roles in metabolism and inflammation. Sirtuin (silent mating type information regulation 2 homolog) 1, or SIRT1, activation is an unexplored therapeutic approach for the treatment of ulcerative colitis (UC). METHODS: Patients wi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sands, Bruce E., Joshi, Shashidhar, Haddad, Jonathan, Freudenberg, Johannes M., Oommen, Deepa Elizabeth, Hoffmann, Ethan, McCallum, Stewart W., Jacobson, Eric
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Lippincott Williams & Wilkins 2015
Materias:	Original Clinical Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4885523/ https://www.ncbi.nlm.nih.gov/pubmed/26595549 http://dx.doi.org/10.1097/MIB.0000000000000597

Ejemplares similares

Cardiovascular Effects of a Novel SIRT1 Activator, SRT2104, in Otherwise Healthy Cigarette Smokers
por: Venkatasubramanian, Sowmya, et al.
Publicado: (2013)

Cardiometabolic effects of a novel SIRT1 activator, SRT2104, in people with type 2 diabetes mellitus
por: Noh, Radzi M, et al.
Publicado: (2017)

A Randomized, Placebo-Controlled Study of SRT2104, a SIRT1 Activator, in Patients with Moderate to Severe Psoriasis
por: Krueger, James G., et al.
Publicado: (2015)

A Pilot Randomized, Placebo Controlled, Double Blind Phase I Trial of the Novel SIRT1 Activator SRT2104 in Elderly Volunteers
por: Libri, Vincenzo, et al.
Publicado: (2012)

Effects of the small molecule SIRT1 activator, SRT2104 on arterial stiffness in otherwise healthy cigarette smokers and subjects with type 2 diabetes mellitus
por: Venkatasubramanian, Sowmya, et al.
Publicado: (2016)

Sirtuin 1 activator SRT2104 protects Huntington's disease mice
por: Jiang, Mali, et al.
Publicado: (2014)

Neuroprotection of SRT2104 in Murine Ischemia/Reperfusion Injury Through the Enhancement of Sirt1-Mediated Deacetylation
por: Bai, Xue, et al.
Publicado: (2023)

SRT2104 extends survival of male mice on a standard diet and preserves bone and muscle mass
por: Mercken, Evi M, et al.
Publicado: (2014)

The Impact of SRT2104 on Skeletal Muscle Mitochondrial Function, Redox Biology, and Loss of Muscle Mass in Hindlimb Unloaded Rats
por: Wesolowski, Lauren T., et al.
Publicado: (2023)

The Sirt1 Activators SRT2183 and SRT3025 Inhibit RANKL-Induced Osteoclastogenesis in Bone Marrow-Derived Macrophages and Down-Regulate Sirt3 in Sirt1 Null Cells
por: Gurt, Irina, et al.
Publicado: (2015)

SRT2379, a small-molecule SIRT1 activator, fails to reduce cytokine release in a human endotoxemia model
por: Wiewel, Maryse A, et al.
Publicado: (2013)

SRT2183 and SRT1720, but not Resveratrol, Inhibit Osteoclast Formation and Resorption in the Presence or Absence of Sirt1
por: Thiyagarajan, Ramkumar, et al.
Publicado: (2023)

SRT1720 as an SIRT1 activator for alleviating paraquat-induced models of Parkinson's disease
por: Chao, Chih-Chang, et al.
Publicado: (2022)

Intraperitoneal injection of the SIRT1 activator SRT1720 attenuates the progression of experimental osteoarthritis in mice
por: Nishida, K., et al.
Publicado: (2018)

PROJECT ADMINISTRATION AGREEMENT KN2104/TE
por: THE EUROPEAN ORGANIZATION FOR NUCLEAR RESEARCH, CERN, et al.
Publicado: (2012)

PROJECT ADMINISTRATION AGREEMENT KN2104/TE
por: THE EUROPEAN ORGANIZATION FOR NUCLEAR RESEARCH, CERN, et al.
Publicado: (2012)

Célula ram SRT /
por: Ortega Vargas José Jaime
Publicado: (2002)

SIRT1 activator (SRT1720) improves the follicle reserve and prolongs the ovarian lifespan of diet-induced obesity in female mice via activating SIRT1 and suppressing mTOR signaling
por: Zhou, Xiao-Ling, et al.
Publicado: (2014)

The Sirt1 activator SRT3025 provides atheroprotection in Apoe(−/−) mice by reducing hepatic Pcsk9 secretion and enhancing Ldlr expression
por: Miranda, Melroy X., et al.
Publicado: (2015)

Internet-based Prescription of Sildenafil: A 2104-Patient Series
por: Jones, Miles J
Publicado: (2001)

A novel dressing seeded with embryonic artery CD133(+) cells and loaded with the Sirt1 agonist SRT1720 accelerates the healing of diabetic ischemic ulcers
por: Cheng, Pan-Ke, et al.
Publicado: (2018)

SRT1720‐induced activation of SIRT1 alleviates vascular smooth muscle cell senescence through PKA‐dependent phosphorylation of AMPKα at Ser485
por: Sung, Jin Young, et al.
Publicado: (2020)

Structural Differences between the Streptococcus agalactiae Housekeeping and Pilus-Specific Sortases: SrtA and SrtC1
por: Khare, B., et al.
Publicado: (2011)

Medical Therapy of Active Ulcerative Colitis
por: Bürger, Martin, et al.
Publicado: (2015)

Software Process & SRT Configuration Management Tool
por: BUCKHART, Doris
Publicado: (2000)

Role of SrtA in Pathogenicity of Staphylococcus lugdunensis
por: Hussain, Muzaffar, et al.
Publicado: (2020)

CBCT Verification of SRT for Patients With Brain Metastases
por: Papp, Judit, et al.
Publicado: (2022)

The sirtuin 1 activator SRT1720 alleviated endotoxin-induced fulminant hepatitis in mice
por: Zhou, Dan, et al.
Publicado: (2021)

Interrogation of Bacillus anthracis SrtA active site loop forming open/close lid conformations through extensive MD simulations for understanding binding selectivity of SrtA inhibitors
por: Selvaraj, Chandrabose, et al.
Publicado: (2021)

Atractylenolide III Improves Mitochondrial Function and Protects Against Ulcerative Colitis by Activating AMPK/SIRT1/PGC-1α
por: Han, Jieru, et al.
Publicado: (2022)

Ulcerative Colitis-Symptom Questionnaire: Valid for Use in Adults with Moderately to Severely Active Ulcerative Colitis
por: Panes, Julian, et al.
Publicado: (2023)

Implementation of superficial radiation therapy (SRT) using SRT‐100 Vision™ for non‐melanoma skin cancer in a Radiation Oncology clinic
por: Lee, Yongsook C., et al.
Publicado: (2023)

PReS-FINAL-2104: Disease course and predictors of outcome in systemic onset juvenile idiopathic arthritis
por: Soponkanaporn, S, et al.
Publicado: (2013)

Adequacy of Pain Treatment in Radiotherapy Departments: Results of a Multicenter Study on 2104 Patients (Arise)
por: Donati, Costanza M., et al.
Publicado: (2022)

PB2104: SOLUBLE B-CELL MATURATION ANTIGEN AS A MONITORING MARKER FOR MULTIPLE MYELOMA
por: Wiedemann, Ádám, et al.
Publicado: (2023)

SRT1720 improves survival and healthspan of obese mice
por: Minor, Robin K., et al.
Publicado: (2011)

An immobilization and localization technique for SRT and IMRT of intracranial tumors
por: Leybovich, Leonid B., et al.
Publicado: (2002)

PTV margin determination in conformal SRT of intracranial lesions
por: Parker, Brent C., et al.
Publicado: (2002)

SRT2183 impairs ovarian cancer by facilitating autophagy
por: Sun, Tingting, et al.
Publicado: (2020)

Algorithms for optoacoustically controlled selective retina therapy (SRT)
por: Seifert, Eric, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_6i00eqclbnpr8di6nhrnip1220