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Isolated Loss of PMS2 Immunohistochemical Expression is Frequently Caused by Heterogenous MLH1 Promoter Hypermethylation in Lynch Syndrome Screening for Endometrial Cancer Patients

Lynch syndrome (LS) is an autosomal-dominant inherited disorder mainly caused by a germline mutation in the DNA mismatch repair (MMR) genes (MLH1, MSH2, MSH6, and PMS2) and is associated with increased risk for various cancers, particularly colorectal cancer and endometrial cancer (EC). Women with L...

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Detalles Bibliográficos
Autores principales:	Kato, Aya, Sato, Naoki, Sugawara, Tae, Takahashi, Kazue, Kito, Masahiko, Makino, Kenichi, Sato, Toshiharu, Shimizu, Dai, Shirasawa, Hiromistu, Miura, Hiroshi, Sato, Wataru, Kumazawa, Yukiyo, Sato, Akira, Kumagai, Jin, Terada, Yukihiro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Wolters Kluwer Health, Inc 2016
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4885527/ https://www.ncbi.nlm.nih.gov/pubmed/26848797 http://dx.doi.org/10.1097/PAS.0000000000000606

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