Cargando…

The protein kinase promiscuities in the cancer-preventive mechanisms of NSAIDs

NSAIDs have been observed to have cancer-preventive properties, but the actual mechanism is elusive. We hypothesize that NSAIDs might have an effect through common pathways and targets of anticancer drugs by exploiting promiscuities of anticancer drug targets. Here, we have explored NSAIDs by their...

Descripción completa

Detalles Bibliográficos
Autores principales:	Norvaisas, Povilas, Chan, Diana, Yokoi, Kenji, Dave, Bhuvanesh, Ziemys, Arturas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Lippincott Williams & Wilkins 2016
Materias:	Research Paper: Carcinogenesis
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4885542/ https://www.ncbi.nlm.nih.gov/pubmed/25714784 http://dx.doi.org/10.1097/CEJ.0000000000000129

Ejemplares similares

Inactivation of homeodomain‐interacting protein kinase 2 promotes oral squamous cell carcinoma metastasis through inhibition of P53‐dependent E‐cadherin expression
por: Zheng, Xueqing, et al.
Publicado: (2020)

Morphology dynamics in intestinal crypt during postnatal development affect age-dependent susceptibility to radiation-induced intestinal tumorigenesis in Apc(Min/+) mice: possible mechanisms of radiation tumorigenesis
por: Sasatani, Megumi, et al.
Publicado: (2022)

Lapatinib-induced annexin A6 upregulation as an adaptive response of triple-negative breast cancer cells to EGFR tyrosine kinase inhibitors
por: Widatalla, Sarrah E, et al.
Publicado: (2019)

Epigenetic repression of E-cadherin by human papillomavirus 16 E7 protein
por: Laurson, Joanna, et al.
Publicado: (2010)

The phosphorylated retinoid X receptor-α promotes diethylnitrosamine-induced hepatocarcinogenesis in mice through the activation of β-catenin signaling pathway
por: Sakai, Hiroyasu, et al.
Publicado: (2021)

A yes-associated protein 1- Notch1 receptor positive feedback loop promotes breast cancer lung metastasis by attenuating the bone morphogenetic protein 4-SMAD family member 1/5 signaling
por: Zhao, Lin, et al.
Publicado: (2022)

Prolonged unfolded protein reaction is involved in the induction of chronic myeloid leukemia cell death upon oprozomib treatment
por: Wang, Fang, et al.
Publicado: (2020)

Manual de métodos para la identificación de mutágenos y carcinógenos químicos ambientales
Publicado: (1980)

RAGE, carboxylated glycans and S100A8/A9 play essential roles in colitis-associated carcinogenesis
por: Turovskaya, Olga, et al.
Publicado: (2008)

CpG methylation in exon 1 of transcription factor 4 increases with age in normal gastric mucosa and is associated with gene silencing in intestinal-type gastric cancers
por: Kim, Seung-Kyoon, et al.
Publicado: (2008)

Constitutive expression of human keratin 14 gene in mouse lung induces premalignant lesions and squamous differentiation
por: Habib Dakir, EL, et al.
Publicado: (2008)

Predominant modifier of extreme liver cancer susceptibility in C57BR/cdJ female mice localized to 6 Mb on chromosome 17
por: Peychal, Stephanie E.-M., et al.
Publicado: (2009)

Transcription coactivator PBP/MED1-deficient hepatocytes are not susceptible to diethylnitrosamine-induced hepatocarcinogenesis in the mouse
por: Matsumoto, Kojiro, et al.
Publicado: (2010)

MiR-138 induces cell cycle arrest by targeting cyclin D3 in hepatocellular carcinoma
por: Wang, Wen, et al.
Publicado: (2012)

Association between hMLH1 hypermethylation and JC virus (JCV) infection in human colorectal cancer (CRC)
por: Vilkin, Alex, et al.
Publicado: (2010)

Interaction of SET domains with histones and nucleic acid structures in active chromatin
por: Krajewski, Wladyslaw A., et al.
Publicado: (2011)

Activation of the mTOR pathway by low levels of xenoestrogens in breast epithelial cells from high-risk women
por: Goodson, William H., et al.
Publicado: (2011)

Monocyclic aromatic amines as potential human carcinogens: old is new again
por: Skipper, Paul L., et al.
Publicado: (2010)

Both base excision repair and O(6)-methylguanine-DNA methyltransferase protect against methylation-induced colon carcinogenesis
por: Wirtz, Stefan, et al.
Publicado: (2010)

Involvement of p53 in the cytotoxic activity of the NAMPT inhibitor FK866 in myeloid leukemic cells
por: Thakur, Basant Kumar, et al.
Publicado: (2013)

Beneficial bacteria stimulate host immune cells to counteract dietary and genetic predisposition to mammary cancer in mice
por: Lakritz, Jessica R, et al.
Publicado: (2014)

De novo-generated small palindromes are characteristic of amplicon boundary junction of double minutes
por: Zhu, Jing, et al.
Publicado: (2013)

Areca nut exposure increases secretion of tumor‐promoting cytokines in gingival fibroblasts that trigger DNA damage in oral keratinocytes
por: Illeperuma, Rasika P., et al.
Publicado: (2015)

Loss of PPARγ expression in mammary secretory epithelial cells creates a pro-breast tumorigenic environment
por: Apostoli, Anthony J, et al.
Publicado: (2014)

Expulsion of micronuclei containing amplified genes contributes to a decrease in double minute chromosomes from malignant tumor cells
por: Ji, Wei, et al.
Publicado: (2014)

Calcium-sensing receptor silencing in colorectal cancer is associated with promoter hypermethylation and loss of acetylation on histone 3
por: Fetahu, Irfete S, et al.
Publicado: (2014)

Identification of cancer biomarkers of prognostic value using specific gene regulatory networks (GRN): a novel role of RAD51AP1 for ovarian and lung cancers
por: Chudasama, Dimple, et al.
Publicado: (2018)

A novel experimental model for human mixed acinar–ductal pancreatic cancer
por: Doiron, Bruno, et al.
Publicado: (2018)

Induction of non-apoptotic programmed cell death by oncogenic RAS in human epithelial cells and its suppression by MYC overexpression
por: Dendo, Kasumi, et al.
Publicado: (2018)

Application of the key characteristics of carcinogens in cancer hazard identification
por: Guyton, Kathryn Z, et al.
Publicado: (2018)

Extra-virgin olive oil contains a metabolo-epigenetic inhibitor of cancer stem cells
por: Corominas-Faja, Bruna, et al.
Publicado: (2018)

The transformics assay: first steps for the development of an integrated approach to investigate the malignant cell transformation in vitro
por: Mascolo, Maria Grazia, et al.
Publicado: (2018)

AFF4 promotes tumorigenesis and tumor-initiation capacity of head and neck squamous cell carcinoma cells by regulating SOX2
por: Deng, Peng, et al.
Publicado: (2018)

Intestinal microbiota enhances pancreatic carcinogenesis in preclinical models
por: Thomas, Ryan M, et al.
Publicado: (2018)

Carbonyl reduction of NNK by recombinant human lung enzymes: identification of HSD17β12 as the reductase important in (R)-NNAL formation in human lung
por: Ashmore, Joseph H, et al.
Publicado: (2018)

The molecular landscape of synchronous colorectal cancer reveals genetic heterogeneity
por: Wang, Xiangfeng, et al.
Publicado: (2018)

Ribose-5-phosphate isomerase A overexpression promotes liver cancer development in transgenic zebrafish via activation of ERK and β-catenin pathways
por: Chou, Yu-Ting, et al.
Publicado: (2019)

Cell line-based xenograft mouse model of paediatric glioma stem cells mirrors the clinical course of the patient
por: Larsson, Susanna, et al.
Publicado: (2018)

DRP1 promotes lactate utilization in KRAS‐mutant non‐small‐cell lung cancer cells
por: Hu, Mangze, et al.
Publicado: (2020)

Targeting RNA helicase DHX33 blocks Ras‐driven lung tumorigenesis in vivo
por: Wang, Xingshun, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_e7l3pt2iilf4mg7lpfta4pi3lm