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Expression of SCGB1C1 gene as a potential marker of susceptibility to upper respiratory tract infections in elite athletes – a pilot study

High levels of exercise in athletes result in temporary immunosuppression, which could increase the susceptibility to upper respiratory tract infections. Understanding of immunological mechanisms responsible for this phenomenon could enable optimization of training schemes for elite athletes and avo...

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Autores principales: Orysiak, J, Malczewska-Lenczowska, J, Bik-Multanowski, M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Institute of Sport in Warsaw 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4885620/
https://www.ncbi.nlm.nih.gov/pubmed/27274102
http://dx.doi.org/10.5604/20831862.1196510
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author Orysiak, J
Malczewska-Lenczowska, J
Bik-Multanowski, M
author_facet Orysiak, J
Malczewska-Lenczowska, J
Bik-Multanowski, M
author_sort Orysiak, J
collection PubMed
description High levels of exercise in athletes result in temporary immunosuppression, which could increase the susceptibility to upper respiratory tract infections. Understanding of immunological mechanisms responsible for this phenomenon could enable optimization of training schemes for elite athletes and avoidance of infection-related episodes of absence during sports championships. The aim of this study was to detect genes that may be responsible for modulation of individual susceptibility to infections. The blood and saliva samples were collected from 10 healthy, medically examined kayakers (4 females and 6 males) aged 24.7 ± 2.3 years. All samples were taken in the morning, after overnight fasting, in a seated position. The ELISA method was used to determine the levels of secretory immunoglobulin A (sIgA) and interleukin 5 (IL-5). Whole genome expression in blood was assessed using microarrays. The study did not reveal any significant correlation between genome expression and sIgA concentration. However, low expression of a gene involved in protection against the common cold – secretoglobin 1C1 (SCGB1C1) – was detected in athletes with high IL-5 concentrations (corrected p = 0.00065; fold change = 3.17). Our results suggest that blood expression of the SCGB1C1 gene might be a marker of susceptibility to upper respiratory tract infections in athletes.
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spelling pubmed-48856202016-06-07 Expression of SCGB1C1 gene as a potential marker of susceptibility to upper respiratory tract infections in elite athletes – a pilot study Orysiak, J Malczewska-Lenczowska, J Bik-Multanowski, M Biol Sport Original Article High levels of exercise in athletes result in temporary immunosuppression, which could increase the susceptibility to upper respiratory tract infections. Understanding of immunological mechanisms responsible for this phenomenon could enable optimization of training schemes for elite athletes and avoidance of infection-related episodes of absence during sports championships. The aim of this study was to detect genes that may be responsible for modulation of individual susceptibility to infections. The blood and saliva samples were collected from 10 healthy, medically examined kayakers (4 females and 6 males) aged 24.7 ± 2.3 years. All samples were taken in the morning, after overnight fasting, in a seated position. The ELISA method was used to determine the levels of secretory immunoglobulin A (sIgA) and interleukin 5 (IL-5). Whole genome expression in blood was assessed using microarrays. The study did not reveal any significant correlation between genome expression and sIgA concentration. However, low expression of a gene involved in protection against the common cold – secretoglobin 1C1 (SCGB1C1) – was detected in athletes with high IL-5 concentrations (corrected p = 0.00065; fold change = 3.17). Our results suggest that blood expression of the SCGB1C1 gene might be a marker of susceptibility to upper respiratory tract infections in athletes. Institute of Sport in Warsaw 2016-03-06 2016-06 /pmc/articles/PMC4885620/ /pubmed/27274102 http://dx.doi.org/10.5604/20831862.1196510 Text en Copyright © Biology of Sport 2016 http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial 3.0 Unported License, permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Orysiak, J
Malczewska-Lenczowska, J
Bik-Multanowski, M
Expression of SCGB1C1 gene as a potential marker of susceptibility to upper respiratory tract infections in elite athletes – a pilot study
title Expression of SCGB1C1 gene as a potential marker of susceptibility to upper respiratory tract infections in elite athletes – a pilot study
title_full Expression of SCGB1C1 gene as a potential marker of susceptibility to upper respiratory tract infections in elite athletes – a pilot study
title_fullStr Expression of SCGB1C1 gene as a potential marker of susceptibility to upper respiratory tract infections in elite athletes – a pilot study
title_full_unstemmed Expression of SCGB1C1 gene as a potential marker of susceptibility to upper respiratory tract infections in elite athletes – a pilot study
title_short Expression of SCGB1C1 gene as a potential marker of susceptibility to upper respiratory tract infections in elite athletes – a pilot study
title_sort expression of scgb1c1 gene as a potential marker of susceptibility to upper respiratory tract infections in elite athletes – a pilot study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4885620/
https://www.ncbi.nlm.nih.gov/pubmed/27274102
http://dx.doi.org/10.5604/20831862.1196510
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