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ALK inhibitor resistance in ALK(F1174L)-driven neuroblastoma is associated with AXL activation and induction of EMT

The crizotinib-resistant ALK(F1174L) mutation arises de novo in neuroblastoma (NB) and is acquired in ALK translocation-driven cancers, lending impetus to the development of novel anaplastic lymphoma kinase (ALK) inhibitors with different modes of action. The diaminopyrimidine TAE684 and its derivat...

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Detalles Bibliográficos
Autores principales:	Debruyne, D N, Bhatnagar, N, Sharma, B, Luther, W, Moore, N F, Cheung, N-K, Gray, N S, George, R E
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4885798/ https://www.ncbi.nlm.nih.gov/pubmed/26616860 http://dx.doi.org/10.1038/onc.2015.434

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