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Spontaneous Tumor Development in Bone Marrow Rescued DNA-PKcs(3A/3A) Mice Due to Dysfunction of Telomere Leading Strand Deprotection

Phosphorylation of the DNA-dependent protein kinase catalytic subunit (DNA-PKcs) at the Thr2609 cluster is essential for its complete function in DNA repair and tissue stem cell homeostasis. This phenomenon is demonstrated by congenital bone marrow failure occurring in DNA-PKcs(3A/3A) mutant mice, w...

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Detalles Bibliográficos
Autores principales:	Zhang, Shichuan, Matsunaga, Shinji, Lin, Yu-Fen, Sishc, Brock, Shang, Zengfu, Sui, Jiangdong, Shih, Hung-Ying, Zhao, Yong, Foreman, Oded, Story, Michael D., Chen, David J., Chen, Benjamin PC.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4885801/ https://www.ncbi.nlm.nih.gov/pubmed/26616856 http://dx.doi.org/10.1038/onc.2015.459

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