Sézary Syndrome and Atopic Dermatitis: Comparison of Immunological Aspects and Targets

Sézary syndrome (SS), an aggressive form of erythrodermic pruritic cutaneous T cell lymphoma (CTCL), from an immunological perspective characterized by increased Th2 cytokine levels, elevated serum IgE and impaired cellular immunity. Not only the clinical appearance but also the hallmark immunologic...

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Autores principales: Saulite, Ieva, Hoetzenecker, Wolfram, Weidinger, Stephan, Cozzio, Antonio, Guenova, Emmanuella, Wehkamp, Ulrike
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4886049/
https://www.ncbi.nlm.nih.gov/pubmed/27294147
http://dx.doi.org/10.1155/2016/9717530
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author Saulite, Ieva
Hoetzenecker, Wolfram
Weidinger, Stephan
Cozzio, Antonio
Guenova, Emmanuella
Wehkamp, Ulrike
author_facet Saulite, Ieva
Hoetzenecker, Wolfram
Weidinger, Stephan
Cozzio, Antonio
Guenova, Emmanuella
Wehkamp, Ulrike
author_sort Saulite, Ieva
collection PubMed
description Sézary syndrome (SS), an aggressive form of erythrodermic pruritic cutaneous T cell lymphoma (CTCL), from an immunological perspective characterized by increased Th2 cytokine levels, elevated serum IgE and impaired cellular immunity. Not only the clinical appearance but also the hallmark immunological characteristics of SS often share striking similarities with acute flares of atopic dermatitis (AD), a common benign chronic inflammatory skin disease. Given the overlap of several immunological features, the application of similar or even identical therapeutic approaches in certain stages of both diseases may come into consideration. The aim of this review is to compare currently accepted immunological aspects and possible therapeutic targets in AD and SS.
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spelling pubmed-48860492016-06-12 Sézary Syndrome and Atopic Dermatitis: Comparison of Immunological Aspects and Targets Saulite, Ieva Hoetzenecker, Wolfram Weidinger, Stephan Cozzio, Antonio Guenova, Emmanuella Wehkamp, Ulrike Biomed Res Int Review Article Sézary syndrome (SS), an aggressive form of erythrodermic pruritic cutaneous T cell lymphoma (CTCL), from an immunological perspective characterized by increased Th2 cytokine levels, elevated serum IgE and impaired cellular immunity. Not only the clinical appearance but also the hallmark immunological characteristics of SS often share striking similarities with acute flares of atopic dermatitis (AD), a common benign chronic inflammatory skin disease. Given the overlap of several immunological features, the application of similar or even identical therapeutic approaches in certain stages of both diseases may come into consideration. The aim of this review is to compare currently accepted immunological aspects and possible therapeutic targets in AD and SS. Hindawi Publishing Corporation 2016 2016-05-17 /pmc/articles/PMC4886049/ /pubmed/27294147 http://dx.doi.org/10.1155/2016/9717530 Text en Copyright © 2016 Ieva Saulite et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Saulite, Ieva
Hoetzenecker, Wolfram
Weidinger, Stephan
Cozzio, Antonio
Guenova, Emmanuella
Wehkamp, Ulrike
Sézary Syndrome and Atopic Dermatitis: Comparison of Immunological Aspects and Targets
title Sézary Syndrome and Atopic Dermatitis: Comparison of Immunological Aspects and Targets
title_full Sézary Syndrome and Atopic Dermatitis: Comparison of Immunological Aspects and Targets
title_fullStr Sézary Syndrome and Atopic Dermatitis: Comparison of Immunological Aspects and Targets
title_full_unstemmed Sézary Syndrome and Atopic Dermatitis: Comparison of Immunological Aspects and Targets
title_short Sézary Syndrome and Atopic Dermatitis: Comparison of Immunological Aspects and Targets
title_sort sézary syndrome and atopic dermatitis: comparison of immunological aspects and targets
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4886049/
https://www.ncbi.nlm.nih.gov/pubmed/27294147
http://dx.doi.org/10.1155/2016/9717530
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