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Surveillance of bloodstream infections in pediatric cancer centers – what have we learned and how do we move on?

Pediatric patients receiving conventional chemotherapy for malignant disease face an increased risk of bloodstream infection (BSI). Since BSI may represent an acute life-threatening event in patients with profound immunosuppression, and show further negative impact on quality of life and anticancer...

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Autores principales: Simon, Arne, Furtwängler, Rhoikos, Graf, Norbert, Laws, Hans Jürgen, Voigt, Sebastian, Piening, Brar, Geffers, Christine, Agyeman, Philipp, Ammann, Roland A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: German Medical Science GMS Publishing House 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4886351/
https://www.ncbi.nlm.nih.gov/pubmed/27274442
http://dx.doi.org/10.3205/dgkh000271
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author Simon, Arne
Furtwängler, Rhoikos
Graf, Norbert
Laws, Hans Jürgen
Voigt, Sebastian
Piening, Brar
Geffers, Christine
Agyeman, Philipp
Ammann, Roland A.
author_facet Simon, Arne
Furtwängler, Rhoikos
Graf, Norbert
Laws, Hans Jürgen
Voigt, Sebastian
Piening, Brar
Geffers, Christine
Agyeman, Philipp
Ammann, Roland A.
author_sort Simon, Arne
collection PubMed
description Pediatric patients receiving conventional chemotherapy for malignant disease face an increased risk of bloodstream infection (BSI). Since BSI may represent an acute life-threatening event in patients with profound immunosuppression, and show further negative impact on quality of life and anticancer treatment, the prevention of BSI is of paramount importance to improve and guarantee patients’ safety during intensive treatment. The great majority of all pediatric cancer patients (about 85%) have a long-term central venous access catheter in use (type Broviac or Port; CVAD). Referring to the current surveillance definitions a significant proportion of all BSI in pediatric patients with febrile neutropenia is categorized as CVAD-associated BSI. This state of the art review summarizes the epidemiology and the distinct pathogen profile of BSI in pediatric cancer patients from the perspective of infection surveillance. Problems in executing the current surveillance definition in this patient population are discussed and a new concept for the surveillance of BSI in pediatric cancer patients is outlined.
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spelling pubmed-48863512016-06-07 Surveillance of bloodstream infections in pediatric cancer centers – what have we learned and how do we move on? Simon, Arne Furtwängler, Rhoikos Graf, Norbert Laws, Hans Jürgen Voigt, Sebastian Piening, Brar Geffers, Christine Agyeman, Philipp Ammann, Roland A. GMS Hyg Infect Control Article Pediatric patients receiving conventional chemotherapy for malignant disease face an increased risk of bloodstream infection (BSI). Since BSI may represent an acute life-threatening event in patients with profound immunosuppression, and show further negative impact on quality of life and anticancer treatment, the prevention of BSI is of paramount importance to improve and guarantee patients’ safety during intensive treatment. The great majority of all pediatric cancer patients (about 85%) have a long-term central venous access catheter in use (type Broviac or Port; CVAD). Referring to the current surveillance definitions a significant proportion of all BSI in pediatric patients with febrile neutropenia is categorized as CVAD-associated BSI. This state of the art review summarizes the epidemiology and the distinct pathogen profile of BSI in pediatric cancer patients from the perspective of infection surveillance. Problems in executing the current surveillance definition in this patient population are discussed and a new concept for the surveillance of BSI in pediatric cancer patients is outlined. German Medical Science GMS Publishing House 2016-05-12 /pmc/articles/PMC4886351/ /pubmed/27274442 http://dx.doi.org/10.3205/dgkh000271 Text en Copyright © 2016 Simon et al. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 License.
spellingShingle Article
Simon, Arne
Furtwängler, Rhoikos
Graf, Norbert
Laws, Hans Jürgen
Voigt, Sebastian
Piening, Brar
Geffers, Christine
Agyeman, Philipp
Ammann, Roland A.
Surveillance of bloodstream infections in pediatric cancer centers – what have we learned and how do we move on?
title Surveillance of bloodstream infections in pediatric cancer centers – what have we learned and how do we move on?
title_full Surveillance of bloodstream infections in pediatric cancer centers – what have we learned and how do we move on?
title_fullStr Surveillance of bloodstream infections in pediatric cancer centers – what have we learned and how do we move on?
title_full_unstemmed Surveillance of bloodstream infections in pediatric cancer centers – what have we learned and how do we move on?
title_short Surveillance of bloodstream infections in pediatric cancer centers – what have we learned and how do we move on?
title_sort surveillance of bloodstream infections in pediatric cancer centers – what have we learned and how do we move on?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4886351/
https://www.ncbi.nlm.nih.gov/pubmed/27274442
http://dx.doi.org/10.3205/dgkh000271
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