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Catechol-O-Methyltransferase Val158Met Polymorphism and Clinical Response to Antipsychotic Treatment in Schizophrenia and Schizo-Affective Disorder Patients: a Meta-Analysis

BACKGROUND: The catechol-O-methyltransferase (COMT) enzyme plays a crucial role in dopamine degradation, and the COMT Val158Met polymorphism (rs4680) is associated with significant differences in enzymatic activity and consequently dopamine concentrations in the prefrontal cortex. Multiple studies h...

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Detalles Bibliográficos
Autores principales:	Huang, Eric, Zai, Clement C., Lisoway, Amanda, Maciukiewicz, Malgorzata, Felsky, Daniel, Tiwari, Arun K., Bishop, Jeffrey R., Ikeda, Masashi, Molero, Patricio, Ortuno, Felipe, Porcelli, Stefano, Samochowiec, Jerzy, Mierzejewski, Pawel, Gao, Shugui, Crespo-Facorro, Benedicto, Pelayo-Terán, José M, Kaur, Harpreet, Kukreti, Ritushree, Meltzer, Herbert Y., Lieberman, Jeffrey A., Potkin, Steven G., Müller, Daniel J., Kennedy, James L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4886669/ https://www.ncbi.nlm.nih.gov/pubmed/26745992 http://dx.doi.org/10.1093/ijnp/pyv132

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