Time to change from a simple linear model to a complex systems model

A simple linear model to test the hypothesis based on one-on-one relationship has been used to find the causative factors of diseases. However, we now know that not just one, but many factors from different systems such as chemical exposure, genes, epigenetic changes, and proteins are involved in th...

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Autor principal: Hong, Yun-Chul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Environmental Health and Toxicology 2016
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4886826/
https://www.ncbi.nlm.nih.gov/pubmed/27158003
http://dx.doi.org/10.5620/eht.e2016008
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author Hong, Yun-Chul
author_facet Hong, Yun-Chul
author_sort Hong, Yun-Chul
collection PubMed
description A simple linear model to test the hypothesis based on one-on-one relationship has been used to find the causative factors of diseases. However, we now know that not just one, but many factors from different systems such as chemical exposure, genes, epigenetic changes, and proteins are involved in the pathogenesis of chronic diseases such as diabetes mellitus. So, with availability of modern technologies to understand the intricate nature of relations among complex systems, we need to move forward to the future by taking complex systems model.
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spelling pubmed-48868262016-06-08 Time to change from a simple linear model to a complex systems model Hong, Yun-Chul Environ Health Toxicol Commentary A simple linear model to test the hypothesis based on one-on-one relationship has been used to find the causative factors of diseases. However, we now know that not just one, but many factors from different systems such as chemical exposure, genes, epigenetic changes, and proteins are involved in the pathogenesis of chronic diseases such as diabetes mellitus. So, with availability of modern technologies to understand the intricate nature of relations among complex systems, we need to move forward to the future by taking complex systems model. The Korean Society of Environmental Health and Toxicology 2016-04-26 /pmc/articles/PMC4886826/ /pubmed/27158003 http://dx.doi.org/10.5620/eht.e2016008 Text en Copyright © 2016 The Korean Society of Environmental Health and Toxicology This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Commentary
Hong, Yun-Chul
Time to change from a simple linear model to a complex systems model
title Time to change from a simple linear model to a complex systems model
title_full Time to change from a simple linear model to a complex systems model
title_fullStr Time to change from a simple linear model to a complex systems model
title_full_unstemmed Time to change from a simple linear model to a complex systems model
title_short Time to change from a simple linear model to a complex systems model
title_sort time to change from a simple linear model to a complex systems model
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4886826/
https://www.ncbi.nlm.nih.gov/pubmed/27158003
http://dx.doi.org/10.5620/eht.e2016008
work_keys_str_mv AT hongyunchul timetochangefromasimplelinearmodeltoacomplexsystemsmodel

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