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Analysis of ABCG2 and other urate transporters in uric acid homeostasis in chronic kidney disease: potential role of remote sensing and signaling

BACKGROUND: In the setting of chronic kidney disease (CKD), altered extra-renal urate handling may be necessary to regulate plasma uric acid. The Remote Sensing and Signaling Hypothesis (Nigam S. What do drug transporters really do? Nat Rev Drug Discov 2015; 14: 29–44) suggests that multispecific so...

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Detalles Bibliográficos
Autores principales:	Bhatnagar, Vibha, Richard, Erin L., Wu, Wei, Nievergelt, Caroline M., Lipkowitz, Michael S., Jeff, Janina, Maihofer, Adam X., Nigam, Sanjay K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2016
Materias:	Chronic Kidney Disease
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4886906/ https://www.ncbi.nlm.nih.gov/pubmed/27274832 http://dx.doi.org/10.1093/ckj/sfw010

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