Functional Restoration of gp91phox-Oxidase Activity by BAC Transgenesis and Gene Targeting in X-linked Chronic Granulomatous Disease iPSCs

Chronic granulomatous disease (CGD) is an inherited immunodeficiency, caused by the inability of neutrophils to produce functional NADPH oxidase required for fighting microbial infections. The X-linked form of CGD (X-CGD), which is due to mutations in the CYBB (gp91phox) gene, a component of NADPH o...

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Detalles Bibliográficos
Autores principales: Laugsch, Magdalena, Rostovskaya, Maria, Velychko, Sergiy, Richter, Cornelia, Zimmer, Ariane, Klink, Barbara, Schröck, Evelin, Haase, Michael, Neumann, Katrin, Thieme, Sebastian, Roesler, Joachim, Brenner, Sebastian, Anastassiadis, Konstantinos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4886927/
https://www.ncbi.nlm.nih.gov/pubmed/26316390
http://dx.doi.org/10.1038/mt.2015.154

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